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ChemicalBook >> CAS DataBase List >> (E)-2-(4-Ethoxyphenylamino)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide

(E)-2-(4-Ethoxyphenylamino)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide

(E)-2-(4-Ethoxyphenylamino)-N′-((2-hydroxynaphthalen-1-yl)methylene)acetohydrazide price.
5 prices
Selected condition：
Brand
  • AK Scientific
  • American Custom Chemicals Corporation
  • TRC
  • Usbiological
Package
  • 10MG
  • 25MG
  • 100mg
  • ManufacturerAK Scientific
  • Product numberSYN5372
  • Product descriptionVU0029767
  • Packaging100mg
  • Price$1053
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008288
  • Product descriptionVU0029767 95.00%
  • Packaging10MG
  • Price$282.45
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0008288
  • Product descriptionVU0029767 95.00%
  • Packaging25MG
  • Price$833.16
  • Updated2021-12-16
  • Buy
  • ManufacturerTRC
  • Product numberV787655
  • Product descriptionVU0029767
  • Packaging25mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerUsbiological
  • Product number468781
  • Product descriptionVU0029767
  • Packaging25mg
  • Price$552
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific SYN5372 VU0029767 100mg $1053 2021-12-16 Buy
American Custom Chemicals Corporation API0008288 VU0029767 95.00% 10MG $282.45 2021-12-16 Buy
American Custom Chemicals Corporation API0008288 VU0029767 95.00% 25MG $833.16 2021-12-16 Buy
TRC V787655 VU0029767 25mg $225 2021-12-16 Buy
Usbiological 468781 VU0029767 25mg $552 2021-12-16 Buy

Properties

Density :1.21±0.1 g/cm3(Predicted)
storage temp. :room temp
solubility :DMSO: >10mg/mL
form :powder
pka :8.26±0.50(Predicted)
color :gray-brown

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Description

VU0029767 is a selective, novel M1 positive allosteric modulator. M1 is a member of the muscarinic acetylcholine family of GPCRs (mAChRs). VU0029767 increases both potency and efficacy of acetylcholine (ACh) at M1. VU0029767 also potentiates a mutant M1 receptor, as well as the effects of allosteric agonist TBPB. VU0029767 weakly increases ACh potency at M1 in phospholipase C and phospholipase D assays. This compound was discovered in conjuction with VU0090157 (different chemotype), another M1 modulator, which differs in its activities at the mutant form of M1, potentiation of TBPB, and phospholipase assays. The two modulators differentially regulate G protein signaling following M1 activation. Thus, VU0029767 and VU0090157 are valuable compounds when used together to tease out ligand-directed trafficking.