1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE
|
- $32 - $3669
- Product name: 1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE
- CAS: 105431-72-9
- MF: C26H21N3O
- MW: 391.46
- EINECS:
- MDL Number:MFCD06245587
- Synonyms:LINOPIRDINE DIHYDROCHLORIDE;1,3-DIHYDRO-1-PHENYL-3,3-BIS(4-PYRIDINYLMETHYL)-2H-INDOL-2-ONE DIHYDROCHLORIDE;LINOPIRDINE (DUP996);Linopirdine2HCl;DuP 996, 1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one;1-Phenyl-3,3-bis(4-pyridinylmethyl)-2,3-dihydro-1H-indole-2-one;1-phenyl-3,3-bis(pyridin-4-ylmethyl)indolin-2-one;linopiridine
19 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Cayman Chemical
- ChemScene
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 1mg
- 50
- 5mg
- 10
- 10mg
- 50mg
- 100mg
- 250mg
- 1g
- 5g
- 25g
- ManufacturerAK Scientific
- Product numberSYN5540
- Product descriptionLinopirdine
- Packaging10mg
- Price$160
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberSYN5540
- Product descriptionLinopirdine
- Packaging50mg
- Price$547
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003182
- Product descriptionLINOPIRDINE 95.00%
- Packaging10MG
- Price$693
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0003182
- Product descriptionLINOPIRDINE 95.00%
- Packaging50MG
- Price$1068.38
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB6916
- Product descriptionLinopirdine
- Packaging10mg
- Price$282
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number19547
- Product descriptionLinopirdine
- Packaging1mg
- Price$32
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19547
- Product descriptionLinopirdine
- Packaging5mg
- Price$121
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number19547
- Product descriptionLinopirdine
- Packaging10mg
- Price$195
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0039654
- Product descriptionLinopirdine 98.83%
- Packaging100mg
- Price$138
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0039654
- Product descriptionLinopirdine 98.83%
- Packaging250mg
- Price$229
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0039654
- Product descriptionLinopirdine 98.83%
- Packaging1g
- Price$459
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0039654
- Product descriptionLinopirdine 98.83%
- Packaging5g
- Price$1376
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0039654
- Product descriptionLinopirdine 98.83%
- Packaging25g
- Price$3669
- Updated2021-12-16
- Buy
- ManufacturerSigma-Aldrich
- Product numberL134
- Product descriptionLinopirdine ≥98% (HPLC)
- Packaging10mg
- Price$229
- Updated2024-03-01
- Buy
- ManufacturerSigma-Aldrich
- Product numberL134
- Product descriptionLinopirdine ≥98% (HPLC)
- Packaging50mg
- Price$915
- Updated2024-03-01
- Buy
- ManufacturerTocris
- Product number1999
- Product descriptionLinopirdinedihydrochloride ≥99%(HPLC)
- Packaging10
- Price$195
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | SYN5540 | Linopirdine | 10mg | $160 | 2021-12-16 | Buy |
| AK Scientific | SYN5540 | Linopirdine | 50mg | $547 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003182 | LINOPIRDINE 95.00% | 10MG | $693 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0003182 | LINOPIRDINE 95.00% | 50MG | $1068.38 | 2021-12-16 | Buy |
| ApexBio Technology | B6916 | Linopirdine | 10mg | $282 | 2021-12-16 | Buy |
| Cayman Chemical | 19547 | Linopirdine | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 19547 | Linopirdine | 5mg | $121 | 2024-03-01 | Buy |
| Cayman Chemical | 19547 | Linopirdine | 10mg | $195 | 2024-03-01 | Buy |
| ChemScene | CS-0039654 | Linopirdine 98.83% | 100mg | $138 | 2021-12-16 | Buy |
| ChemScene | CS-0039654 | Linopirdine 98.83% | 250mg | $229 | 2021-12-16 | Buy |
| ChemScene | CS-0039654 | Linopirdine 98.83% | 1g | $459 | 2021-12-16 | Buy |
| ChemScene | CS-0039654 | Linopirdine 98.83% | 5g | $1376 | 2021-12-16 | Buy |
| ChemScene | CS-0039654 | Linopirdine 98.83% | 25g | $3669 | 2021-12-16 | Buy |
| Sigma-Aldrich | L134 | Linopirdine ≥98% (HPLC) | 10mg | $229 | 2024-03-01 | Buy |
| Sigma-Aldrich | L134 | Linopirdine ≥98% (HPLC) | 50mg | $915 | 2024-03-01 | Buy |
| Tocris | 1999 | Linopirdinedihydrochloride ≥99%(HPLC) | 10 | $195 | 2021-12-16 | Buy |
Properties
Melting point :186-186.5 °C
Boiling point :655.9±50.0 °C(Predicted)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :Desiccate at RT
solubility :DMSO: >10mg/mL
pka :6.01±0.10(Predicted)
form :A crystalline solid
color :white to off-white
Boiling point :655.9±50.0 °C(Predicted)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :Desiccate at RT
solubility :DMSO: >10mg/mL
pka :6.01±0.10(Predicted)
form :A crystalline solid
color :white to off-white
Safety Information
| Symbol(GHS): |
|
|||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal word: | Warning | |||||||||||||||||||||||||||||||||||
| Hazard statements: |
|
|||||||||||||||||||||||||||||||||||
| Precautionary statements: |
|
Description
Linopirdine is an enhancer of the stimulus-evoked but not basal release of several neurotransmitters, including acetylcholine, dopamine, serotonin, and glutamate. It increases acetylcholine release in rat hippocampal CA1 neurons by blocking voltage-gated, calcium-activated and leak (M-type; Kv7.2/7.3; KCNQ2/3) K+ current with an IC50 value of 2.4 μM. Inhibition of M-channels is reported to result in the depolarization of CA3 pyramidal neurons and activated presynaptic voltage-gated P/Q- and N-type calcium channels, which leads to Ca2+ influx and increased neurotransmitter release. Linopirdine has been shown to produce a number of effects including EEG patterns of enhanced vigilance, induction of c-fos expression in cerebral cortex, reduction of the increase of cerebral glucose utilization induced by hypoxia, and improved performance in animal models of learning and memory. Linopirdine has also been identified as an agonist of transient receptor potential vanilloid type 1 (EC50 = 115 μM in HEK293 cells voltage clamped at -60 mV).Related product price
- 1149-23-1
$6-1870 - 23210-22-2
$17.8-653.31 - 105431-72-9
$32-3669
