Chemical Safety Data Sheet MSDS / SDS

Dextromethorphan

Revision Date:2024-12-21Revision Number:1

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Product name: Dextromethorphan
CBnumber: CB1699713
CAS: 125-71-3
EINECS Number: 204-752-2
Synonyms: DEXTROMETHORPHAN,Dex

Relevant identified uses of the substance or mixture and uses advised against

Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
Uses advised against: none

Company Identification

Company: Chemicalbook
Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
Telephone: 400-158-6606

SECTION 2: Hazards identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Label elements

Pictogram(s)

Signal wordDanger

Hazard statement(s)

H225 Highly Flammable liquid and vapour

H301 Toxic if swalloed

H336 May cause drowsiness or dizziness

H370 Causes damage to organs

Precautionary statement(s)

P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260 Do not breathe dust/fume/gas/mist/vapours/spray.

P280 Wear protective gloves/protective clothing/eye protection/face protection.

P311 Call a POISON CENTER or doctor/physician.

P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Prevention

P264 Wash ... thoroughly after handling.

P270 Do not eat, drink or smoke when using this product.

Response

P301+P316 IF SWALLOWED: Get emergency medical help immediately.

P321 Specific treatment (see ... on this label).

P330 Rinse mouth.

Storage

P405 Store locked up.

Disposal

P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards

no data available

SECTION 3: Composition/information on ingredients

Substance

Product name: Dextromethorphan
Synonyms: DEXTROMETHORPHAN,Dex
CAS: 125-71-3
EC number: 204-752-2
MF: C18H25NO
MW: 271.4

SECTION 4: First aid measures

Description of first aid measures

If inhaled

Move the victim into fresh air. If breathing is difficult, give oxygen. If not breathing, give artificial respiration and consult a doctor immediately. Do not use mouth to mouth resuscitation if the victim ingested or inhaled the chemical.

Following skin contact

Take off contaminated clothing immediately. Wash off with soap and plenty of water. Consult a doctor.

Following eye contact

Rinse with pure water for at least 15 minutes. Consult a doctor.

Following ingestion

Rinse mouth with water. Do not induce vomiting. Never give anything by mouth to an unconscious person. Call a doctor or Poison Control Center immediately.

Most important symptoms and effects, both acute and delayed

no data available

Indication of any immediate medical attention and special treatment needed

Emergency and supportive measures: Most patients with mild symptoms (ie, restlessness, ataxia, or mild drowsiness) can be observed for 4-6 hours and discharged if their condition is improving. Maintain an open airway and assist ventilation if needed. Treat seizures and coma if they occur.

SECTION 5: Firefighting measures

Extinguishing media

Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Advise for firefighters: Wear self contained breathing apparatus for fire fighting if necessary. Dextromethorphan hydrobromide

Specific Hazards Arising from the Chemical

no data available

Advice for firefighters

Wear self-contained breathing apparatus for firefighting if necessary.

NFPA 704

HEALTH	0	Poses no health hazard, no precautions necessary and would offer no hazard beyond that of ordinary combustible materials
FIRE	3	Liquids and solids (including finely divided suspended solids) that can be ignited under almost all ambient temperature conditions . Liquids having a flash point below 22.8 °C (73 °F) and having a boiling point at or above 37.8 °C (100 °F) or having a flash point between 22.8 and 37.8 °C (73 and 100 °F). (e.g. gasoline, acetone)
REACT	0	Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2)
SPEC. HAZ.

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Avoid dust formation. Avoid breathing mist, gas or vapours.Avoid contacting with skin and eye. Use personal protective equipment.Wear chemical impermeable gloves. Ensure adequate ventilation.Remove all sources of ignition. Evacuate personnel to safe areas.Keep people away from and upwind of spill/leak.

Environmental precautions

Prevent further spillage or leakage if it is safe to do so. Do not let the chemical enter drains. Discharge into the environment must be avoided.

Methods and materials for containment and cleaning up

Accidental release measures: Personal precautions: Avoid dust formation. Avoid breathing vapors, mist or gas. Environmental precautions: Do not let product enter drains. Methods and materials for containment and cleaning up: Sweep up and shovel. Keep in suitable, closed containers for disposal. Dextromethorphan hydrobromide

SECTION 7: Handling and storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Lozenges: store between 15 and 30 degrees C in well closed containers. Syrup USP: Store between 15 and 30 degrees C in light, resistant container, protected from freezing.

SECTION 8: Exposure controls/personal protection

Control parameters

Occupational Exposure limit values

no data available

Biological limit values

no data available

Exposure controls

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Individual protection measures

Eye/face protection

Wear tightly fitting safety goggles with side-shields conforming to EN 166(EU) or NIOSH (US).

Skin protection

Wear fire/flame resistant and impervious clothing. Handle with gloves. Gloves must be inspected prior to use. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.

Respiratory protection

If the exposure limits are exceeded, irritation or other symptoms are experienced, use a full-face respirator.

Thermal hazards

no data available

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

Physical state
Solid
Colour
White to slightly yellow crystalline powder
Odour
Odorless
Melting point/freezing point
122-124
Boiling point or initial boiling point and boiling range
394.9°C at 760 mmHg
Flammability
no data available
Lower and upper explosion limit/flammability limit
no data available
Flash point
116.2°C
Auto-ignition temperature
no data available
Decomposition temperature
no data available
pH
no data available
Kinematic viscosity
no data available
Solubility
no data available
Partition coefficient n-octanol/water
no data available
Vapour pressure
1.92E-06mmHg at 25°C
Density and/or relative density
1.11 g/cm3
Relative vapour density
no data available
Particle characteristics
no data available

SECTION 10: Stability and reactivity

Reactivity

no data available

Chemical stability

Stable under recommended storage conditions. Dextromethorphan hydrobromide

Possibility of hazardous reactions

no data available

Conditions to avoid

no data available

Incompatible materials

Strong oxidizing agents. Dextromethorphan hydrobromide

Hazardous decomposition products

Carbon oxides, nitrogen oxides (NOx), Hydrogen bromide gas. Dextromethorphan hydrobromide

SECTION 11: Toxicological information

Acute toxicity

Oral: LD50 Mouse oral 201 mg/kg
Inhalation: no data available
Dermal: no data available

Skin corrosion/irritation

no data available

Serious eye damage/irritation

no data available

Respiratory or skin sensitization

no data available

Germ cell mutagenicity

no data available

Carcinogenicity

no data available

Reproductive toxicity

no data available

STOT-single exposure

no data available

STOT-repeated exposure

no data available

Aspiration hazard

no data available

SECTION 12: Ecological information

Toxicity

Toxicity to fish: no data available
Toxicity to daphnia and other aquatic invertebrates: no data available
Toxicity to algae: no data available
Toxicity to microorganisms: no data available

Persistence and degradability

no data available

Bioaccumulative potential

The estimated pKa of dextromehtorphan is 9.85(1), indicating that dextromethorphan will exist almost entirely in the cation form at pH values of 5 to 9 and, therefore, bioconcentration in fish is not expected to be an important fate process(SRC).

Mobility in soil

Using a structure estimation method based on molecular connectivity indices(1), the Koc of dextromethorphan can be estimated to be 2.3X10+4(SRC). According to a classification scheme(2), this estimated Koc value suggests that dextromethorphan is expected to be immobile in soil. The estimated pKa of dextromethorphan is 9.85(3), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4).

Other adverse effects

no data available

SECTION 13: Disposal considerations

Disposal methods

Product

The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.

Contaminated packaging

Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.

SECTION 14: Transport information

UN Number

ADR/RID: UN3249 (For reference only, please check.)

IMDG: UN3249 (For reference only, please check.)

IATA: UN3249 (For reference only, please check.)

UN Proper Shipping Name

ADR/RID: MEDICINE, SOLID, TOXIC, N.O.S. (For reference only, please check.)

IMDG: MEDICINE, SOLID, TOXIC, N.O.S. (For reference only, please check.)

IATA: MEDICINE, SOLID, TOXIC, N.O.S. (For reference only, please check.)

Transport hazard class(es)

ADR/RID: 6.1 (For reference only, please check.)

IMDG: 6.1 (For reference only, please check.)

IATA: 6.1 (For reference only, please check.)

Packing group, if applicable

ADR/RID: II (For reference only, please check.)

IMDG: II (For reference only, please check.)

IATA: II (For reference only, please check.)

Environmental hazards

ADR/RID: No

IMDG: No

IATA: No

Special precautions for user

no data available

Transport in bulk according to IMO instruments

no data available

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

European Inventory of Existing Commercial Chemical Substances (EINECS)

Listed.

EC Inventory

Listed.

United States Toxic Substances Control Act (TSCA) Inventory

Not Listed.

China Catalog of Hazardous chemicals 2015

Not Listed.

New Zealand Inventory of Chemicals (NZIoC)

Not Listed.

PICCS

Listed.

Vietnam National Chemical Inventory

Listed.

IECSC

Not Listed.

Korea Existing Chemicals List (KECL)

Not Listed.

SECTION 16: Other information

Abbreviations and acronyms

CAS: Chemical Abstracts Service
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
IMDG: International Maritime Dangerous Goods
IATA: International Air Transportation Association
TWA: Time Weighted Average
STEL: Short term exposure limit
LC50: Lethal Concentration 50%
LD50: Lethal Dose 50%
EC50: Effective Concentration 50%

References

IPCS - The International Chemical Safety Cards (ICSC), website: http://www.ilo.org/dyn/icsc/showcard.home
HSDB - Hazardous Substances Data Bank, website: https://toxnet.nlm.nih.gov/newtoxnet/hsdb.htm
IARC - International Agency for Research on Cancer, website: http://www.iarc.fr/
eChemPortal - The Global Portal to Information on Chemical Substances by OECD, website: http://www.echemportal.org/echemportal/index?pageID=0&request_locale=en
CAMEO Chemicals, website: http://cameochemicals.noaa.gov/search/simple
ChemIDplus, website: http://chem.sis.nlm.nih.gov/chemidplus/chemidlite.jsp
ERG - Emergency Response Guidebook by U.S. Department of Transportation, website: http://www.phmsa.dot.gov/hazmat/library/erg
Germany GESTIS-database on hazard substance, website: http://www.dguv.de/ifa/gestis/gestis-stoffdatenbank/index-2.jsp
ECHA - European Chemicals Agency, website: https://echa.europa.eu/

Disclaimer:

The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.

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Dextromethorphan

SECTION 1: Identification of the substance/mixture and of the company/undertaking

Product identifier

Relevant identified uses of the substance or mixture and uses advised against

Company Identification

SECTION 2: Hazards identification

Classification of the substance or mixture

Label elements

Other hazards

SECTION 3: Composition/information on ingredients

Substance

SECTION 4: First aid measures

Description of first aid measures

Most important symptoms and effects, both acute and delayed

Indication of any immediate medical attention and special treatment needed

SECTION 5: Firefighting measures

Extinguishing media

Specific Hazards Arising from the Chemical

Advice for firefighters

NFPA 704

SECTION 6: Accidental release measures

Personal precautions, protective equipment and emergency procedures

Environmental precautions

Methods and materials for containment and cleaning up

SECTION 7: Handling and storage

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

SECTION 8: Exposure controls/personal protection

Control parameters

Exposure controls

Individual protection measures

SECTION 9: Physical and chemical properties

Information on basic physicochemical properties

SECTION 10: Stability and reactivity

Reactivity

Chemical stability

Possibility of hazardous reactions

Conditions to avoid

Incompatible materials

Hazardous decomposition products

SECTION 11: Toxicological information

Acute toxicity

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

SECTION 12: Ecological information

Toxicity

Persistence and degradability

Bioaccumulative potential

Mobility in soil

Other adverse effects

SECTION 13: Disposal considerations

Disposal methods

SECTION 14: Transport information

UN Number

UN Proper Shipping Name

Transport hazard class(es)

Packing group, if applicable

Environmental hazards

Special precautions for user

Transport in bulk according to IMO instruments

SECTION 15: Regulatory information

Safety, health and environmental regulations specific for the product in question

SECTION 16: Other information

Abbreviations and acronyms

References