午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> journal list >> Expert Opinion on Drug Safety >>article
Expert Opinion on Drug Safety

Expert Opinion on Drug Safety

IF: 3
Download PDF

Safety evaluation of trabectedin in treatment of soft-tissue sarcomas.

Published:1 November 2013 DOI: 10.1517/14740338.2013.829037 PMID: 23937190
Juan Martin-Liberal, Ian Judson

Abstract

Introduction: Trabectedin gained the approval by the European Medicines Agency (EMA) in 2007 for the treatment of patients affected by soft-tissue sarcomas (STS). Its safety and activity profiles have been assessed in many clinical trials as well as in standard clinical practice for > 10 years.

Areas covered: This article extensively reviews the most common and specific adverse events associated with trabectedin. Moreover, we compare these toxicity data with other drugs active in STS such as doxorubicin and ifosfamide. Also, we provide a comprehensive view of the special mechanism of action of this drug and its clinical applications. Additionally, we discuss the current role of trabectedin in the treatment of STS and give a future perspective with the review of ongoing clinical trials and potential new indications.

Expert opinion: Trabectedin is, in general, a well-tolerated drug with a favorable toxicity profile. The majority of its side effects are mild and easily manageable. Specific adverse events such as liver toxicity and rhabdomyolysis do not usually have a significant clinical impact. Overall, trabectedin is a safe and active treatment option in STS.

Substances (3)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Ifosfamide 3778-73-2 C7H15Cl2N2O2P 487 suppliers $5.00-$846.60
Adriamycin 23214-92-8 C27H29NO11 261 suppliers Inquiry
Trabectedin 114899-77-3 C39H43N3O11S 158 suppliers $1000.00-$55440.00

Similar articles

IF:4.4

The Role of Trabectedin in Soft Tissue Sarcoma

Frontiers in Pharmacology Tomoki Nakamura,?A. Sudo,etc Published: 23 February 2022
IF:4.9

The Influence of Strontium on Bone Tissue Metabolism and Its Application in Osteoporosis Treatment.

International Journal of Molecular Sciences Barbara Ko?odziejska, Natalia St?pień,etc Published: 18 June 2021