Alkaloid induced asymmetric electrocarboxylation of 4-methylpropiophenone
Published:25 May 2011
DOI: 10.1016/j.tetlet.2011.03.076
Shu-Feng Zhao, Mei-Xia Zhu, Kai Zhang, Huan Wang, Jia-Xing Lu
Abstract
The alkaloid-induced electrocarboxylation of 4-methylpropiophenone is examined in mild conditions. Comparative studies with several inductors indicate that the efficient enantiodiscrimination of the electrocarboxylation depends on the nucleophilic quinuclidine nitrogen atom and the OH group of the inductors.