午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> journal list >> International Journal of Pharmaceutics >>article
International Journal of Pharmaceutics

International Journal of Pharmaceutics

IF: 5.29
Download PDF

An antigen/chemotherapy co-loaded DNA nanocube inserts into tumor cell plasma membrane and enhances chemo-and immunotherapy

Published:9 December 2024 DOI: 10.1016/j.ijpharm.2024.125068 PMID: 39662859
Jun Cao,?Junhong Sun,?Yuzhen Zhang,?Zhuolin Dong,?Mengru Li,?Fenfen Liu,?Ayesha Younas,?Nan Zhang,?Yibing Chen

Abstract

Breast cancer is the most frequently diagnosed female cancer. Combined chemo- and immunotherapies have been extensively explored to treat breast cancer. To improve the efficacy of the combined therapies, this study designed a hollow DNA nanocube with four cholesterol anchors (C2.2) that could be inserted into breast cancer cell plasma membrane. A model antigen-ovalbumin (OVA257-264) was further conjugated to C2.2 to construct C2.2-OVA and a model chemotherapy-Doxorubicin (DOX) was also loaded to C2.2-OVA to prepare DOX@C2.2-OVA for the combined chemo- and immunotherapy to treat breast cancer. C2.2, C2.2-OVA, and DOX@C2.2-OVA were successfully prepared and possessed square-like shape and small size. C2.2 and C2.2-OVA could be anchored in breast cancer cell plasma membrane for at least 10?h. C2.2-OVA demonstrated the significantly higher activation rates of DC cells than free OVA. Although C2.2 showed no cytotoxicity, C2.2 increased the potency of 5-FU and carboplatin to MCF-7 and 4?T1 breast cancer cells. DOX@C2.2-OVA treatment to 4?T1 tumor in vivo showed the significant reduction of tumor size and weight, and resulted in more DCs and CD8+ T cells in 4?T1 tumor. In summary, DOX@C2.2-OVA that could be inserted into tumor cell plasma membrane enhanced the combined chemo- and immunotherapy for the breast cancer treatment.

Substances (13)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Acetic acid 64-19-7 C2H4O2 1630 suppliers $10.00-$8459.00
Ethylenediaminetetraacetic acid 60-00-4 C10H16N2O8 1169 suppliers $10.00-$6397.62
Tris(hydroxymethyl)aminomethane 77-86-1 C4H11NO3 1137 suppliers $5.00-$8920.00
5-Fluorouracil 51-21-8 C4H3FN2O2 944 suppliers $5.00-$2492.67
Urea 57-13-6 CH4N2O 777 suppliers $5.00-$9263.00
Ammonium persulfate 7727-54-0 H8N2O8S2 682 suppliers $13.98-$3100.00
Acrylamide 79-06-1 C3H5NO 665 suppliers $18.00-$1470.00
N,N,N',N'-Tetramethylethylenediamine 110-18-9 C6H16N2 604 suppliers $10.00-$2091.40
Trypsin 9002-07-7 C35H47N7O10 453 suppliers $17.70-$24930.00
Agarose 9012-36-6 C10H15N3O3 327 suppliers $25.50-$2810.00

Similar articles

IF:10

Hybrid Cell Membrane‐Coated Nanoparticles for Synergizing Sonodynamic Therapy and Immunotherapy against Triple‐Negative Breast Cancer

Advanced Healthcare Materials Jiali Gong, Danling Cheng,etc Published: 21 November 2024
IF:2.9

Ethylhexylglycerin Impairs Membrane Integrity and Enhances the Lethal Effect of Phenoxyethanol

PLoS ONE S. Langsrud,?K. Steinhauer,etc Published: 26 October 2016