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International Journal of Biological Macromolecules

International Journal of Biological Macromolecules

IF: 7.7
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Pullulan-spermine enhance the tolerance of probiotics and immune stimulation of macrophages

Published:9 December 2024 DOI: 10.1016/j.ijbiomac.2024.138417 PMID: 39662548
Zihui Meng,?Qinghui He,?Litong Mu,?Jiaying Feng,?Fei Zhang,?Jiayi Wu,?Li Zhou,?Qingang Hu,?Xuna Tang,?Yanan Li

Abstract

The application of probiotics as adjunctive therapy in colorectal cancer treatment is hindered by the paucity of strains with specialized functions and the instability of their in vivo efficacy. The design of innovative and simple encapsulation strategies to enhance their stability and efficacy of probiotics has garnered substantial interest. This study investigated four Bifidobacterium longum strains from human feces for tolerance and cytotoxicity, and then synthesized a cationic polysaccharide, pullulan-spermine (PS), for probiotic encapsulation. The results indicated that the encapsulation by PS hold superior protective capacity and elevated the level of TNF-α and IL-12. In vivo studies further confirmed the retention capacity and safety of this probiotic-PS complex. Generally, this research presents an effective probiotic encapsulation strategy that could enhance macrophage immune responses, offering novel insights for probiotic-based therapies in major diseases like colon cancer treatment.

Substances (9)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Dimethyl sulfoxide 67-68-5 C2H6OS 1344 suppliers $15.00-$120900.00
1,1'-Carbonyldiimidazole 530-62-1 C7H6N4O 1098 suppliers $6.00-$8350.00
Trypsin 9002-07-7 C35H47N7O10 453 suppliers $17.70-$24930.00
Pepsin 9001-75-6 n.a. 452 suppliers $23.30-$10280.00
Pullulan 9057-02-7 C20H36O16 366 suppliers $24.65-$2740.00
Neutral Red 553-24-2 C15H17ClN4 339 suppliers $14.70-$4231.69
Spermine 71-44-3 C10H26N4 336 suppliers $37.00-$2390.00
FETUIN 9014-81-7 NULL 66 suppliers $37.07-$4380.00
MTT 2348-71-2 C18H16BrN5S 48 suppliers Inquiry

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