午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook >> journal list >> Cell Reports Medicine >>article
Cell Reports Medicine

Cell Reports Medicine

IF: 11.69
Download PDF

Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T?cell immunity to inhibit hepatitis B virus

Published:19 November 2024 DOI: 10.1016/j.xcrm.2024.101822 PMID: 39536754
Tixiao Wang, Yuchen Fan, Chunhong Ma

Abstract

The therapeutic potential of commensal microbes and their metabolites is promising in the functional cure of chronic hepatitis B virus (HBV) infection, which is defined as hepatitis B surface antigen (HBsAg) loss. Here, using both specific-pathogen-free and germ-free mice, we report that probiotics significantly promote the decline of HBsAg and inhibit HBV replication by enhancing intestinal homeostasis and provoking intrahepatic interferon (IFN)-γ+CD4+ T?cell immune response. Depletion of CD4+ T?cells or blockage of IFN-γ abolishes probiotics-mediated HBV inhibition. Specifically, probiotics-derived spermidine accumulates in the gut and transports to the liver, where it exhibits a similar anti-HBV effect. Mechanistically, spermidine enhances IFN-γ+CD4+ T?cell immunity by autophagy. Strikingly, administration of probiotics in HBV patients reveals a preliminary trend to accelerate the decline of serum HBsAg. In conclusion, probiotics and their derived spermidine promote HBV clearance via autophagy-enhanced IFN-γ+CD4+ T?cell immunity, highlighting the therapeutic potential of probiotics and spermidine for the functional cure of HBV patients.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Metronidazole 443-48-1 C6H9N3O3 808 suppliers $19.00-$957.10
Neomycin sulfate 1405-10-3 C23H48N6O17S 789 suppliers $5.00-$1651.10
Ampicillin 69-53-4 C16H19N3O4S 535 suppliers $13.00-$499.00
Entecavir 142217-69-4 C12H15N5O3 519 suppliers $39.00-$1143.00
Vancomycin 1404-90-6 C66H75Cl2N9O24 252 suppliers Inquiry
FLUORESCEIN ISOTHIOCYANATE-DEXTRAN 60842-46-8 76 suppliers $89.70-$1980.00

Similar articles

IF:2.5

Synthesis and Properties of Shape Memory Poly(γ-Benzyl-l-Glutamate)-b-Poly(Propylene Glycol)-b-Poly(γ-Benzyl-l-Glutamate)

Applied Sciences-Basel Lin Gu,?Yuanzhang Jiang,etc Published: 4 December 2017
IF:3.2

Roxadustat for Patients with Post-transplant Anemia: A Narrative Review

Kidney Diseases Xiaoxiao Tang, Fei Liu,etc Published: 10 November 2023
IF:4.6

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of the Hepatitis C Virus NS5B Polymerase Inhibitor Sofosbuvir.

Clinical Pharmacokinetics Brian J Kirby, William T Symonds,etc Published: 1 July 2015