Grifola frondosa Polysaccharide Ameliorates Inflammation by Regulating Macrophage Polarization of Liver in Type 2 Diabetes Mellitus Rats
Published:26 November 2024
DOI: 10.1002/mnfr.202400392
Pei Zou, Xueyan Li, Liping Wang, Ying She, Chenyang Xiao, Yang Peng, Xu Qian, Peng Luo, Shaofeng Wei
Abstract
Grifola frondosa polysaccharide (GFP) has a positive effect in regulating type 2 diabetes mellitus (T2DM), but the understanding of its regulatory mechanism is still limited. Accumulating evidence suggests that hepatic inflammation is crucial in the onset and progression of insulin resistance (IR) and T2DM. However, the question of whether GFP can modulate T2DM via regulating hepatic inflammation and the underlying mechanism has not yet been reported.