產(chǎn)品描述
等級(jí)：活性藥物成分（API）
化學(xué)名稱(chēng)：1-（4-{[2-（1-甲基乙氧基）乙氧基]甲基}苯氧基）-3-[（1-甲基乙基）氨基]2-丙醇(2E)- 2-烯二酸酯（2:1）（鹽）
分子式:C40H66N2O12
分子量:766.96
規(guī)格:ChP / USP / EP / BP / JP
外觀:粉
總雜質(zhì)：不大于0.5%
純度：不低于99%
殘留溶劑：完全符合ICH Q3C要求
致突變雜質(zhì)：完全符合ICH M8
亞硝胺評(píng)估：可用
粒度：可根據(jù)客戶(hù)要求進(jìn)行普通級(jí)或研磨/篩分。
儲(chǔ)存方法：室溫
生產(chǎn)能力：商用
標(biāo)準(zhǔn)包裝：1kg/袋，5kg/袋，或根據(jù)客戶(hù)要求
產(chǎn)品用途
富馬酸比索洛爾是富馬酸鹽的合成苯氧基-2-丙醇衍生的心臟選擇性β -1腎上腺素能受體拮抗劑，具有抗高血壓和潛在的心臟保護(hù)活性。?
比索洛爾是一種心臟選擇性β1-腎上腺素能阻滯劑，用于治療高血壓。它被認(rèn)為是一種半衰期長(zhǎng)的強(qiáng)效藥物，可以每天使用一次，以減少對(duì)多劑量降壓藥的需求。比索洛爾通常耐受性良好，可能是由于其β1-腎上腺素能受體的選擇性，是治療高血壓的非選擇性β受體阻滯劑（如卡維地洛和拉貝他洛）的有用替代品。它可以單獨(dú)使用或與其他藥物聯(lián)合使用來(lái)控制高血壓，并且由于其受體選擇性，可用于慢性阻塞性肺疾?。–OPD）患者。
近年來(lái)，富馬酸比索洛爾也被用于治療心力衰竭。對(duì)于先前接受過(guò)ACE抑制劑、利尿劑和心糖苷類(lèi)藥物（射血分?jǐn)?shù)≤35%）并伴有心室收縮功能障礙的中重度慢性穩(wěn)定型心力衰竭患者有效。
聯(lián)系方式
四川青木制藥有限公司
四川省眉山市東坡區(qū)經(jīng)濟(jì)開(kāi)發(fā)區(qū)東區(qū)順江大道南段55號(hào)
國(guó)際營(yíng)銷(xiāo)部(International):
Email: sales@eastonpharma.cn
Tel: 028-87827187
國(guó)內(nèi)營(yíng)銷(xiāo)部(Mainland)：
李經(jīng)理 13880480517
楊經(jīng)理 15982276454
Product Description
· Grade: Active Pharmaceutical Ingredient(API)
· Chemical Name:1-(4-{[2-(1-methylethoxy)ethoxy]methyl}phenoxy)-3-[(1-methylethyl)amino]propan-2-ol (2E)-but-2-enedioate (2:1) (salt)
· Molecular Formula:C40H66N2O12
· Molecular Weight:766.96
· Specification: ChP/USP/EP/BP/JP
· Appearance: Powder
· Total impurities: not more than 0.5%
· Purity: not less than 99%
· Residual Solvents: fully comply with ICH Q3C
· Mutagenic impurities: fully comply with ICH M8
· Nitrosamine assessment: available
· Particle size: regular grade or milling/sieving according to customer’s requirement.
· Storage: Room temperature
· Production capacity: Commercial
· Standard Package: 1kg/bag, 5kg/bag, or according to the customer’s requirement
Applications of Bisoprolol Fumarate
· Bisoprolol Fumarate is the fumarate salt of a synthetic phenoxy-2-propanol-derived cardioselective beta-1 adrenergic receptor antagonist with antihypertensive and potential cardioprotective activities.
· Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure. It is considered a potent drug with a long half-life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs. Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity, and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as Carvedilol and Labetalol. It may be used alone or in combination with other drugs to manage hypertension and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.
· In recent years, Bisoprolol fumarate has also been used to treat heart failure. It is effective in patients with moderate-to-severe chronic stable heart failure who have previously received ACE inhibitors, diuretics, and cardioside drugs (ejection fraction ≤35%) with ventricular systolic dysfunction.
Contact Information
Sichuan Qingmu Pharmaceutical Co., Ltd.
Add: No. 55, South Shunjiang Avenue, East Economic Development Zone, Dongpo District, Meishan City, Sichuan, 620036, China
International Marketing Department:
Email: sales@eastonpharma.cn
Tel: 0086-28-87827187