Product Details
| Product Name:
AZ12601011 |
CAS No.:
2748337-86-0 |
| Purity:
98.81% |
Supply Ability:
10g |
| Release date:
2024/11/16 |
Product Introduction
Bioactivity
| 名稱 | AZ12601011 |
| 描述 | AZ12601011 is an orally active, selective and potent TGFBR1 kinase inhibitor.AZ12601011 inhibits the release of inflammatory factors, interleukin (IL)-1β, IL-6 and tumor necrosis factor-α, and inhibits the growth of breast tumors.AZ12601011 directly binds to TGF-βR1 and blocks downstream Smad3 activation, which can be used to prevent renal fibrosis. |
| 體外活性 | AZ12601011 (0.01-10 μM; for 20 minutes) entirely inhibits phosphorylation of SMAD2 and the activity of ALK4, ALK7, and TGFBR1. It also inhibits 4T1 cell growth in vitro (IC50 = 0.4 μM). [1] Western Blot Analysis shows complete inhibition of SMAD2 phosphorylation in NIH3T3, HaCaT, C2C12, and T47D cells at concentrations of 0.01-10 μM after 20 minutes of incubation. |
| 體內(nèi)活性 | AZ12601011 (50mg/kg; oral gavage; twice daily; for 25 days) significantly suppresses tumor growth and metastasis in vivo [1]. Administered to female BALB/c mice (weight >18g) bearing tumors, the compound effectively hinders both tumor development and migration. |
| 存儲條件 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| 溶解度 | DMSO : 4 mg/mL (12.76 mM), Sonication is recommended.
|
| 關鍵字 | AZ12601011 |
| 相關產(chǎn)品 | Monocrotaline | DMH-1 | SB-431542 | Hydrochlorothiazide | Crizotinib | Chromenone 1 | Ceritinib | BMP signaling agonist sb4 | Pirfenidone | A 83-01 | Galunisertib | Alantolactone |
| 相關庫 | 細胞重編程化合物庫 | 經(jīng)典已知活性庫 | 細胞因子抑制劑庫 | HIF-1化合物庫 | 抗乳腺癌化合物庫 | 抑制劑庫 | 抗纖維化化合物庫 | 干細胞分化化合物庫 | 口服活性化合物庫 | 已知活性化合物庫 | TGF-β/Smad靶點化合物庫 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$100.00/1mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2024-11-16 |
United States