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Postion:Product Catalog >APX-115
APX-115
  • APX-115

APX-115 NEW

Price $30 $73 $118
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-04-30

Product Details

Product Name: APX-115 CAS No.: 1395946-75-4
Purity: 99.68% Supply Ability: 10g
Release date: 2025/04/30

Product Introduction

Bioactivity

NameAPX-115
DescriptionAPX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury.
In vitroIn the mouse podocyte cell line, APX-115 (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].
In vivoAPX-115 treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice[1].
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 90 mg/mL (285 mM), Sonication is recommended.
KeywordsNOX4 | Nox4 | Nox2 | NOX2 | NOX1 | Nox1 | NADPHoxidase | APX-115 | APX115 | APX 115
Inhibitors RelatedGLX351322 | APX-115 free base | NoxA1ds acetate(1435893-78-9 free base) | NecroX-7 | Ketoconazole | Aucuparin | Protosappanin A | Phox-I2 | ML-090 | GKT136901 | Setanaxib | VAS 3947
Related Compound LibrariesFailed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Diabetic Compound Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Orally Active Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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