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Postion:Product Catalog >APX-115 free base
APX-115 free base
  • APX-115 free base

APX-115 free base NEW

Price $42 $98 $163
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-22

Product Details

Product Name: APX-115 free base CAS No.: 1270084-92-8
Purity: 98.39% Supply Ability: 10g
Release date: 2025/05/22

Product Introduction

Bioactivity

NameAPX-115 free base
DescriptionAPX-115 free base (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor with inhibition constants (Kis) of 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4, respectively, and it effectively prevents kidney injury.
In vitroIn the mouse podocyte cell line, APX-115 free base (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 free base attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].
In vivoAPX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 245 mg/mL (877.07 mM), Sonication is recommended.
Keywordsresistance | plasma | Nox4 | Nox3 | Nox2 | Nox1 | NOX | NADPHoxidase | NADPH Oxidase | kidney | insulin | injury | Inhibitor | inhibit | Ewha-18278 | Ewha18278 | Ewha 18278 | creatinine | APX-115 free base | APX115 free base | APX-115 | APX115 | APX 115 free base | APX 115 | albumin
Inhibitors RelatedMetronidazole | Ketoconazole | Resveratrol | Pasiniazid | ML-090 | APX-115 | Dicoumarol | NAD+ | Apocynin | Triclosan | AKR1C1-IN-1 | Setanaxib
Related Compound LibrariesGlycometabolism Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Anti-Metabolism Disease Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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  • Since: 2011-01-07
  • Address: 36 Washington Street, Wellesley Hill, USA
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