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| | 2-Tetrahydrofurfurylamine Basic information |
| Product Name: | 2-Tetrahydrofurfurylamine | | Synonyms: | 2-TETRAHYDROFURFURYLAMINE;2-AMINOMETHYL-TETRAHYDROFURAN;AKOS BBS-00003587;(n)-tetrahydrofurfurylamine;2-Tetrahydrofurylmethylamine;2-TETRAHYDROFURFURYLAMINE 98+%;(Tetrahydrofuran-2-ylmethyl)amine;2,3,4,5-Tetrahydrofuran-2-methanamine | | CAS: | 4795-29-3 | | MF: | C5H11NO | | MW: | 101.15 | | EINECS: | 225-351-9 | | Product Categories: | Furan&Benzofuran;Amines | | Mol File: | 4795-29-3.mol |  |
| | 2-Tetrahydrofurfurylamine Chemical Properties |
| Melting point | 136 °C | | Boiling point | 153-154 °C744 mm Hg(lit.) | | density | 0.98 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.454(lit.) | | Fp | 114 °F | | storage temp. | Flammables area | | solubility | Chloroform, Methanol | | pka | 9.47±0.29(Predicted) | | form | Liquid | | color | Clear colorless to light yellow | | explosive limit | 1.6-14.1%(V) | | Water Solubility | miscible | | Sensitive | Air Sensitive & Hygroscopic | | BRN | 102729 | | LogP | -0.348 (est) | | CAS DataBase Reference | 4795-29-3(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Furanmethanamine, tetrahydro-(4795-29-3) | | EPA Substance Registry System | Tetrahydrofurfurylamine (4795-29-3) |
| Hazard Codes | Xi | | Risk Statements | 10-36/37/38 | | Safety Statements | 26-36-37/39-16 | | RIDADR | UN 2943 3/PG 3 | | WGK Germany | 3 | | RTECS | LV0175000 | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29321900 |
| | 2-Tetrahydrofurfurylamine Usage And Synthesis |
| Chemical Properties | Colorless to light-yellow liquid. Distilling range 150–
156C, d 0.977 (20C/20C). Combustible. | | Uses | Tetrahydro-2-furanmethanamine is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors | | Uses | Chemical intermediate, fine-grain photographic
development, vulcanization accelerator. | | General Description | A colorless to light yellow liquid. Insoluble in water and less dense than water. Flash point between 100 - 141°F. Used to make other chemicals and as a photographic chemical. | | Air & Water Reactions | Flammable. Insoluble in water. | | Reactivity Profile | 2-Tetrahydrofurfurylamine is an amine and alcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. | | Health Hazard | May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. | | Fire Hazard | HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. | | Safety Profile | Poison by intraperitoneal route. Flammable liquid when exposed to heat or flame. When heated to decomposition it emits toxic fumes of NOx. See also MINES. |
| | 2-Tetrahydrofurfurylamine Preparation Products And Raw materials |
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