Related articles - A brief introduction to Cefiderocol
- Cefiderocol is a novel catechol-substituted siderophore cephalosporin for injection that uses the bacterial active iron transp....
- Jan 4，2024
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| | Cefiderocol Basic information |
| Product Name: | Cefiderocol | | Synonyms: | Cefiderocol;(6R,7R)-7-((Z)-2-(2-Aminothiazol-4-yl)-2-(((2-carboxypropan-2-yl)oxy)imino)acetamido)-3-((1-(2-(2-chloro-3,4-dihydroxybenzamido)ethyl)pyrrolidin-1-ium-1-yl)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;2H8]-Cefiderocol;2H6]-Cefiderocol | | CAS: | 1225208-94-5 | | MF: | C30H34ClN7O10S2 | | MW: | 752.21 | | EINECS: | | | Product Categories: | benzene | | Mol File: | 1225208-94-5.mol |  |
| | Cefiderocol Chemical Properties |
| storage temp. | Store at -20°C, stored under nitrogen,unstable in solution, ready to use. | | solubility | DMSO:50.0(Max Conc. mg/mL);66.47(Max Conc. mM) | | form | Solid | | color | White to off-white |
| | Cefiderocol Usage And Synthesis |
| Uses | Cefiderocol, is a novel parenteral siderophore cephalosporin conjugated with a catechol moiety, that has a characteristic antibacterial spectrum with a potent activity against a broad range of aerobic Gram-negative bacterial species, | | reaction suitability | reagent type: chelator | | Biological Activity | Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.
Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens. Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities. | | IC 50 | β-lactam |
| | Cefiderocol Preparation Products And Raw materials |
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