N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
中文名稱 | N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE |
---|---|
中文同義詞 | 化合物 T4530L;KN-92,KN-93 的非活性衍生物;化合物 KN-92 |
英文名稱 | KN92 |
英文同義詞 | N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE;KN-92;KN 92;KN92;Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-4-methoxy-;K 92;K92;KN-92 free base |
CAS號(hào) | 176708-42-2 |
分子式 | C24H25ClN2O3S |
分子量 | 456.98 |
EINECS號(hào) | |
相關(guān)類(lèi)別 | |
Mol文件 | 176708-42-2.mol |
結(jié)構(gòu)式 | ![]() |
N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE 性質(zhì)
沸點(diǎn) | 602.1±65.0 °C(Predicted) |
---|---|
密度 | 1.282±0.06 g/cm3(Predicted) |
儲(chǔ)存條件 | Store at -20°C |
溶解度 | DMSO 中 ≥ 15.1 mg/mL,EtOH 中 ≥ 24.2 mg/mL,溫和加熱 |
形態(tài) | Solid |
酸度系數(shù)(pKa) | 8.49±0.10(Predicted) |
顏色 | White to off-white |
N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE 用途與合成方法
KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth.
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21.
Cell Viability Assay
Cell Line: | Human hepatic stellate cells (LX-2) |
Concentration: | 5-50 μM |
Incubation Time: | 24 hours |
Result: | Ineffective in blocking cell growth. |