N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
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- CAS號:
- 176708-42-2
- 英文名:
- KN92
- 英文別名:
- K92;K 92;KN-92 free base;KN-92;KN 92;KN92;N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE;Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-4-methoxy-
- 中文名:
- N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
- 中文別名:
- 化合物 KN-92;化合物 T4530L;KN-92,KN-93 的非活性衍生物
- CBNumber:
- CB82666646
- 分子式:
- C24H25ClN2O3S
- 分子量:
- 456.98
- MOL File:
- 176708-42-2.mol
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N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE化學(xué)性質(zhì)
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沸點(diǎn):
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602.1±65.0 °C(Predicted)
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密度:
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1.282±0.06 g/cm3(Predicted)
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儲(chǔ)存條件:
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Store at -20°C
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溶解度:
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≥ 15.1 mg/mL in DMSO, ≥ 24.2 mg/mL in EtOH with gentle warming
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酸度系數(shù)(pKa):
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8.49±0.10(Predicted)
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N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE性質(zhì)、用途與生產(chǎn)工藝
KN-92 是 KN-93 的非活性衍生物，不具有 CaM 激酶抑制活性。KN-92 可作為對照化合物用于闡明KN-93的拮抗活性。KN-93 可滲透細(xì)胞，可逆和競爭性的 CaMKII 抑制劑。
KN-93 (5-50 μM; 24 hours) inhibits LX-2 cell growth and KN-92 (5-50 μM; 24 hours) is ineffective in blocking cell growth.
The analysis of cell cycle regulator expression reveals that KN-93 rather than KN-92 reduces the expression of p53 and p21.
Cell Viability Assay
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Cell Line:
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Human hepatic stellate cells (LX-2)
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Concentration:
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5-50 μM
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Incubation Time:
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24 hours
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Result:
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Ineffective in blocking cell growth.
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N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
上下游產(chǎn)品信息
上游原料
下游產(chǎn)品
N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE
生產(chǎn)廠家
176708-42-2, N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE 相關(guān)搜索:
- 抑制劑
- 藥靶配體
- 化合物 KN-92
- KN-92,KN-93 的非活性衍生物
- 化合物 T4530L
- 176708-42-2
- KN-92 free base
- K92
- K 92
- Benzenesulfonamide, N-[2-[[[3-(4-chlorophenyl)-2-propen-1-yl]methylamino]methyl]phenyl]-4-methoxy-
- KN-92;KN 92;KN92
- N-[2-[[[(E)-3-(4-CHLOROPHENYL)PROP-2-ENYL]-METHYLAMINO]METHYL]PHENYL]-4-METHOXYBENZENESULFONAMIDE