PDK1 抑制劑
| 中文名稱 | PDK1 抑制劑 |
|---|---|
| 中文同義詞 | PDK1 抑制劑;PDK1抑制劑(PDK1 INHIBITOR);1-[(3,4-二氟苯基)甲基]-N-[(1R)-2-[(2,3-二氫-2-氧代-1H-苯并咪唑-5-基)氧基]-1-苯基乙基]-1,2-二氫-2-氧代-3-吡啶甲酰胺;PDK1 抑制劑,10 MM DMSO 溶液 |
| 英文名稱 | PDK1 inhibitor |
| 英文同義詞 | PDK1 inhibitor;1-[(3,4-Difluorophenyl)methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-3-pyridinecarboxamide;3-PyridinecarboxaMide, 1-[(3,4-difluorophenyl)Methyl]-N-[(1R)-2-[(2,3-dihydro-2-oxo-1H-benziMidazol-5-yl)oxy]-1-phenylethyl]-1,2-dihydro-2-oxo-;4-difluorophenyl)methyl]-N-[(1R)-2-[(2;3-dihydro-2-oxo-1H-benzimidazol-5-yl)oxy]-1-phenylethyl]-1;2-dihydro-2-oxo-;MP7;PDK1 inhibitor 7 |
| CAS號(hào) | 1001409-50-2 |
| 分子式 | C28H22F2N4O4 |
| 分子量 | 516.5 |
| EINECS號(hào) | |
| 相關(guān)類別 | 細(xì)胞生物學(xué)試劑 |
| Mol文件 | 1001409-50-2.mol |
| 結(jié)構(gòu)式 |  |
PDK1 抑制劑 性質(zhì)
| 沸點(diǎn) | 724.4±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.398 |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 11.48±0.20(Predicted) |
| 顏色 | 淺黃至黃色 |
PDK1
Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC 50 values in the micromolar range.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/05 | HY-14440 | PDK1 抑制劑 MP7 | 1001409-50-2 | 1 mg | 590元 |
| 2025/02/05 | HY-14440 | PDK1 抑制劑 MP7 | 1001409-50-2 | 5mg | 1300元 |