|
|
| | BETULINIC ACID METHYL ESTER Basic information |
| Product Name: | BETULINIC ACID METHYL ESTER | | Synonyms: | BETULINIC ACID METHYL ESTER;3B-HYDROXY-LUP-20(29)-EN-28-OIC ACID METHYL ESTER;Lup-20(29)-en-28-oic acid, 3-hydroxy-, methyl ester, (3beta)-;Methylbetulinate;BETULINIC ACID METHYL ESTER hplc;BETULINIC ACID METHYLESTER WITH HPLC;Lup-20(29)-en-28-oic acid, 3-hydroxy-, methyl ester, (3β)-;betulinate, Methyl | | CAS: | 2259-06-5 | | MF: | C31H50O3 | | MW: | 470.73 | | EINECS: | 218-857-6 | | Product Categories: | Tri-Terpenoids | | Mol File: | 2259-06-5.mol |  |
| | BETULINIC ACID METHYL ESTER Chemical Properties |
| Melting point | 222-223°C | | Boiling point | 523.5±33.0 °C(Predicted) | | density | 1.036±0.06 g/cm3(Predicted) | | pka | 15.16±0.70(Predicted) | | form | A solid | | LogP | 9.400 (est) |
| | BETULINIC ACID METHYL ESTER Usage And Synthesis |
| Description | Betulinic acid methyl ester is a lupane-type triterpenoid and an esterified version of betulinic acid that has been found in Helicteres hirsuta and has diverse biological activities. It inhibits HIV-1 reverse transcriptase (IC50 = 11 μM). Betulinic acid methyl ester is active against L. braziliensis and T. cruzi (IC50s = 69.9 and 93.3 μM, respectively). It induces melanogenesis in (EC50 = 2.5 μM) and inhibits the growth of B16 2F2 melanoma cells in vitro (IC50 = 4.9 μM). Betulinic acid methyl ester is cytotoxic to SK-LU-1, HepG2, HeLa, SK-MEL-2, and AGS cells (IC50s = 60.84, 77.43, 80.17, 66.17, and 69.94 μg/ml, respectively). | | Definition | ChEBI: Betulinic acid methyl ester is a triterpenoid. | | Biological Activity | Betulinic acid methyl ester is a natural compound extracted from the bark of the birch tree with anti-inflammatory and antiprotozoal activity. Studies have shown it to be a potent inhibitor of cancer cell growth in vitro and in vivo. It has also been shown to have hypoglycaemic effects in mice. |
| | BETULINIC ACID METHYL ESTER Preparation Products And Raw materials |
|