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1-(3-Chlorphenyl)piperazine

1-(3-Chlorphenyl)piperazine Basic information
Product Name:1-(3-Chlorphenyl)piperazine
Synonyms:RARECHEM AH CK 0071;N-(3-CHLOROPHENYL)PIPERAZINE;TIMTEC-BB SBB003579;1-(3-CHLORPHENYL)-PIPERAZINE;1-(3-Chlorophenyl)piperazine 97%;1-(3-CHLOROPHENYL)PIPERAZINE (MCPP);3-chlorophenyl piperazine;AKOS BBS-00003580
CAS:6640-24-0
MF:C10H13ClN2
MW:196.68
EINECS:229-654-7
Product Categories:FOR TRAZODONE'S PRODUCTION;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;PHARMACEUTICAL INTERMEDIATES;Piperidines, Piperidones, Piperazines;Piperaizine;API intermediates;Piperazines;Various Metabolites and Impurities
Mol File:6640-24-0.mol
1-(3-Chlorphenyl)piperazine Structure
1-(3-Chlorphenyl)piperazine Chemical Properties
Melting point 210-214°C
Boiling point 105 °C
density 1.193
refractive index 1,598-1,600
storage temp. -20°C Freezer, Under Inert Atmosphere
solubility Chloroform (Slightly), Methanol (Sparingly)
form Oil
pka8.85±0.10(Predicted)
color Colourless to Orange
LogP2.468
CAS DataBase Reference6640-24-0(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36/37/39-36
HazardClass IRRITANT
HS Code 29339900
MSDS Information
ProviderLanguage
3-Chlorophenyl piperazine English
1-(3-Chlorphenyl)piperazine Usage And Synthesis
Chemical Propertiesclear colorless to light yellow oily liquid
UsesIt is noteworthy that 1-(3-Chlorphenyl)piperazine (m-CPP), resulting from N-dealkylation of Trazodone, is a major circulating metabolite in humans common to several antidepressants including Trazodone, Nefazodone, and Etoperidone (1,2,3). The metabolite m-CPP is of significant interest because it has 5-HT2C agonistic and 5-HT2A antagonistic properties. It has also been suggested that m-CPP may contribute to the antidepressant efficacy of Trazodone.
DefinitionChEBI: A N-arylpiperazine that is piperazine carrying a 3-chlorophenyl substituent at position 1. It is a metabolite of the antidepressant drug trazodone.
HazardA poison.
Tag:1-(3-Chlorphenyl)piperazine(6640-24-0) Related Product Information
1-(3-Chlorphenyl)piperazine 1-(M-CHLOROPHENYL) PIPERAZINE HYDROCHLORIDE,1-(3-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE N-(3,4-DICHLOROPHENYL)PIPERAZINE HYDROCHLORIDE 4-(4-Chlorophenyl)piperazine,1-(4-CHLOROPHENYL)PIPERAZINE 1-(2,3-DICHLOROPHENYL)PIPERAZINE HYDROBROMIDE 3-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-(2,5-Dichlorophenyl)piperazine dihydrochloride 1-(4-Chlorophenyl)piperazin-2-one 1-(2,4-DICHLOROBENZYL)PIPERAZINE 1-(3,5-DICHLOROPHENYL)PIPERAZINE 1-(4-CHLOROPHENYL)PIPERAZINE DIHYDROCHLORIDE,1-(4-CHLOROPHENYL)-PIPERAZINE 2HCL 1-(2,3-Dichlorophenyl)-piperazine 1-(3-CHLOROPROPYL)-4-(3-CHLOROPHENYL)PIPERAZINE HCL 1-(2-CHLOROPHENYL)PIPERAZINE,1-(o-Chlorophenyl)piperazine 1-(2-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE,1-(2-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE 1-(2,3-Dichlorophenyl)piperazine hydrochloride 1-(4-CHLOROPHENYL)PIPERAZINE HYDROCHLORIDE,1-(4-CHLOROPHENYL)PIPERAZINE MONOHYDROCHLORIDE 1-(3-Chlorophenyl)piperazine hydrochloride
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