AH 7614
| 中文名稱 | AH 7614 |
|---|---|
| 中文同義詞 | 化合物AH 7614;AH-7614,FFA4 / GPR120拮抗劑;4-甲基-N-(9H-氧雜蒽-9-基)苯磺酰胺;化合物AH 7614,10 MM DMSO 溶液 |
| 英文名稱 | AH 7614 |
| 英文同義詞 | AH 7614;4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide;Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-;allosteric,linoleic,negative,FFAR,GPR120,FFA4,inhibit,AH7614,AH-7614,NAM,Inhibitor,Free Fatty Acid Receptor,acid;AH-7614, FFA4/GPR120 antagonist;AH-7614, 10 mM in DMSO |
| CAS號 | 6326-06-3 |
| 分子式 | C20H17NO3S |
| 分子量 | 351.42 |
| EINECS號 | |
| 相關(guān)類別 | 抑制劑 |
| Mol文件 | 6326-06-3.mol |
| 結(jié)構(gòu)式 |  |
AH 7614 性質(zhì)
| 熔點 | 196-197 °C(Solv: ethanol (64-17-5); 1,4-dioxane (123-91-1)) |
|---|---|
| 沸點 | 505.9±60.0 °C(Predicted) |
| 密度 | 1.37±0.1 g/cm3(Predicted) |
| 儲存條件 | -20°C (des.) |
| 溶解度 | 溶于DMSO（最高50mg/ml）或乙醇（升溫最高8mg/ml）。 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 10.33±0.20(Predicted) |
| 顏色 | 米白色 |
| 穩(wěn)定性 | 可在-20°下的DMSO或乙醇溶液保存長達1個月。 |
pIC50: 7.1 (human FFA4)
AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca
2+
response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.
AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.
AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC
50
=7.70).
AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.
AH7614 (50?μg; intratumoral injection once every 4?d for 20 d) reduces the tumor growth in mice.
AH7614 (50?μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.