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4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine

4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine

中文名稱4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
中文同義詞4,4?4喬,4喬?(2,3,4,5-Thiophentetrayl)tetrakis-pyridine;2,3,4,5-四(4-吡啶基)噻吩;2,3,4,5-四-(4-吡啶)噻吩;2,3,4,5-四(4-吡啶基)噻吩(GANT58);化合物 GANT 58;GANT58,HH SIGNALING抑制劑;化合物GANT 58,10 MM DMSO 溶液
英文名稱2,3,4,5-TETRA-(4-PYRIDYL) THIOPHENE
英文同義詞¥-(2,3,4,5-Thiophentetrayl)tetrakis-pyridine;,4¥4,4¥Nsc75503;Pyridine, 4,4',4'',4'''-(2,3,4,5-thiophenetetrayl)tetrakis-;GANT58;1,2,3,4-Tetrakis(4-pyridyl)thiophene
CAS號(hào)64048-12-0
分子式C24H16N4S
分子量392.48
EINECS號(hào)200-258-5
相關(guān)類別噻吩類衍生物;有機(jī)化合物
Mol文件64048-12-0.mol
結(jié)構(gòu)式4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine 結(jié)構(gòu)式

4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine 性質(zhì)

熔點(diǎn)252-253℃
沸點(diǎn)414.1±40.0 °C(Predicted)
密度1.254
儲(chǔ)存條件Keep in dark place,Sealed in dry,2-8°C
溶解度二甲基亞砜:>10mg/mL
形態(tài)黃色固體
酸度系數(shù)(pKa)4.50±0.10(Predicted)
顏色白色至淺黃色

4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine 用途與合成方法

GANT 58 是一種有效的 Gli 拮抗劑,抑制 GLI1 誘導(dǎo)的轉(zhuǎn)錄,IC50 為 5 μM。

IC50: 5 μM (Gli)

GANT58 is a downstream inhibitor of Hh signaling. GANT58 is an indeed inhibitor of Hh signaling downstream of Smo and Sufu. GANT58 mainly acts at the nuclear level because transcription induced by GLI1 with a mutated nuclear export signal is still blocked. GANT58 efficiently inhibits in vitro tumor cell proliferation in a GLI-dependent manner and successfully blocks cell growth using human prostate cancer cells harboring downstream activation of the Hh pathway. GANT58 (NSC75503) has been shown to inhibit transcriptional activation by GLI1 (as well as by the other GLI species). GANT58 has been shown to inhibit GLI transactivation.

Nude mice are injected s.c. with GLI1-positive 22Rv1 prostate cancer cells, and tumors are established (median size ≈250 mm 3 ). Nude mice are treated with daily s.c. injections at a concentration of 50 mg/kg of cyclopamine, GANT61, GANT58, or solvent only (n=4-5 for each group). However, after 3 days, cyclopamine-treated animals presented with severe ulcerations at the injection sites. Therefore, changing the treatment regimen to injections only every second day. To be able to compare all compounds, this protocol is also introduced for the GANTs, although mice treated with these compounds showed no such signs of toxicity. All injections are done 2-3 cm away from the tumors. During an 18-day treatment period, suppression of tumor cell growth is observed for all compounds. Treatment with cyclopamine or GANT58 results in the inhibition of additional xenograft growth and limited the increase in tumor size.

安全信息

WGK Germany3

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/05/22HY-132824,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
GANT 58
64048-12-05mg512元
2025/05/22HY-132824,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
GANT 58
64048-12-010mM * 1mLin DMSO563元

4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine 上下游產(chǎn)品信息

"4,44喬,4喬(2,3,4,5-Thiophentetrayl)tetrakis-pyridine"相關(guān)產(chǎn)品信息
噻吩 4,4?4喬,4喬?(2,3,4,5-Thiophentetrayl)tetrakis-pyridine
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