阿維菌素 B1a
中文名稱 | 阿維菌素 B1a |
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中文同義詞 | 阿巴汀;克螨靈;齊螨素;阿維菌素 B1a;愛(ài)弗菌素;依維菌素雜質(zhì)1;伊維菌素EP雜質(zhì)A;伊維菌素雜質(zhì)3 |
英文名稱 | Avermectin B1a |
英文同義詞 | avermectin b1a;ABAMECTIN BETA-CYPERMETHRIN 1%;ABERMECTINS;AverMectin A1a,5-O-deMethyl-;5-o-demethyl-avermectin a1;5-O-DemethylAvermectin A1a;Antibiotic C-076B1a;C-076B1a |
CAS號(hào) | 65195-55-3 |
分子式 | C48H72O14 |
分子量 | 873.09 |
EINECS號(hào) | 265-610-3 |
相關(guān)類別 | 獸用原藥;微生物代謝物;化工原料;農(nóng)業(yè)原料;原料;有機(jī)化工;中間體;原料;API原料藥-獸藥原料藥;原藥中間體 |
Mol文件 | 65195-55-3.mol |
結(jié)構(gòu)式 | ![]() |
阿維菌素 B1a 性質(zhì)
沸點(diǎn) | 940.9±65.0 °C(Predicted) |
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密度 | 1.24±0.1 g/cm3(Predicted) |
儲(chǔ)存條件 | Store at -20°C |
溶解度 | DMSO 中≥143.4 mg/mL; ≥11.86 mg/mL,乙醇溶液,超聲波;不溶于水 |
形態(tài) | 粉末 |
酸度系數(shù)(pKa) | 12.42±0.70(Predicted) |
顏色 | 白色至淺黃色 |
穩(wěn)定性 | 吸濕性 |
EPA化學(xué)物質(zhì)信息 | Avermectin B1a (65195-55-3) |
[ 3 H]AVM B1a preferentially binds to synaptic membranes from several regions of rat brain. [ 3 H]AVM B1a specific binding to intact monolayers of granule cells increases rapidly with time of incubation and reaches equilibrium after approximately 20 min at 24°C. Higher concentrations of [ 3 H]AVM B1a leads to markedly greater nonspecific binding, 60% at 25 nM. Various AVM analogs also produce concentration-dependent inhibition of [ 3 H]AVM B1a binding in intact cerebellar neurons. AVM B1a and moxidectin are similar in potency (IC 50 values, 120 and 126 nM, respectively). AVMB1a-stimulated chloride efflux from mouse brain synaptic vesicles results from the activation of GABA-insensitive chloride channels and that this action is distinct from their previously documented effects on GABA-gated chloride channels in mouse brain preparations.
Bacteria are significantly inhibited when the AVM B1a concentration is higher than 83.3 mg/kg, while fungi are less impaired in soil. Soil respiration is also inhibited by high concentration AVM B1a, which differs with soil types. The half lethal dosage (LD 50 ) of AVM B1a to soil earthworm is estimated as 4.63 mg × cm 2 in filter paper contact test, and as 24.13 and 17.06 mg/kg, respectively after treated 7 and 14 days in artificial soil. Iin artificial soil, the LC50 of AVM B1a on earthworms are 24.1 mg/kg and 17.1 mg/kg, respectively, for 7 and 14 days. About 80.0% and 94.8% of the accumulated AVM B1a are eliminated respectively in two groups within 1 day after they are exposed to AVM B1a-free soil, but a trace amount of AVM B1a is found for a relative long time in earthworms.
安全信息
危險(xiǎn)品運(yùn)輸編號(hào) | 2588 |
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危險(xiǎn)等級(jí) | 6.1(a) |
包裝類別 | II |
毒性 | LD20 orl-rat: 10 mg/kg JAFCAU 32,94,84 |
更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
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2025/05/22 | HY-15308 | 阿維菌素 B1a Avermectin B1a | 65195-55-3 | 5mg | 250元 |
2025/05/22 | HY-15308 | 阿維菌素 B1a Avermectin B1a | 65195-55-3 | 10mM * 1mLin DMSO | 340元 |