| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
18210857532 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:N-(5-AdaMant-1-yl-Methoxy)pentyl DeoxynojiriMycin
CAS:216758-20-2
Package:10Mg,1Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN
CAS:216758-20-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Chemsky（shanghai）International Co.,Ltd.
|
| Tel: |
021-50135380 |
| Email: |
shchemsky@sina.com |
| Products Intro: |
Product Name:N-(5-AdaMant-1-yl-Methoxy)pentyl DeoxynojiriMycin
CAS:216758-20-2
Purity:98%
|
N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN manufacturers
- AMP-Deoxynojirimycin
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- $98.00 / 1mg
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2025-05-01
- CAS:216758-20-2
- Min. Order:
- Purity: 100%
- Supply Ability: 10g
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| | N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Basic information |
| Product Name: | N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN | | Synonyms: | N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN;2R-(HYDROXYMETHYL)-1-[5-(TRICYCLO[3.3.2.13,7]DEC-1-YLMETHOXY)PENTYL]-3R,4R,5S-PIPERIDINETRIOL;ADAMANTANE-PENTYL-DNM;AMP-DEOXYNOJIRIMYCIN;N-(5-AdaMant-1-yl-Methoxy)pentyl DeoxynojiriMycin;AMP-Deoxynojirimycin - Solution in ethanol;AMP-Deoxynojirimycin Exclusive;3,4,5-Piperidinetriol, 2-(hydroxymethyl)-1-[5-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)pentyl]-, (2R,3R,4R,5S)- | | CAS: | 216758-20-2 | | MF: | C22H39NO5 | | MW: | 397.55 | | EINECS: | | | Product Categories: | Amines, Carbohydrates & Derivatives, Inhibitors | | Mol File: | 216758-20-2.mol |  |
| | N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Chemical Properties |
| Boiling point | 569.9±50.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | | form | powder | | pka | 13.72±0.70(Predicted) | | color | white to beige |
| | N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Usage And Synthesis |
| Chemical Properties | Off White Foam | | Uses | A powerful inhibitor of the non-lysomal glucoceramidase at nanomolar concentrations. At these low concentrations, the lysosomal glucocerebrosidase and a-glucosidase, the glucoceramide synthetase, and the N-linked glycantrimming a-glucosidases of the endoplasmic reticulum are not affected. | | Biological Activity | AMP-deoxynojirimycin (AMP-DNM) is an orally available iminosugar th at acts as a reversible, potent and selective inhibitor against the non-lysosomal glucosylceramidase GBA2 (IC50 = 1.7 nM) over the glucosylceramide synthase (GCS, UGCG), ER alpha-glucosidases, the lysosomal glucocerebrosidase GBA (IC50 = 0.16 μM) and alpha-glucosidase GAA (IC50 = 0.87 μM). AMP-DNM selectively inhibits cellular GBA2 in cultures (GBA2/GBA IC50 = 0.3 nM/100 nM; human melanoma cells) and exhibits in vivo therapeutic efficacy in murine models of obesity (100 mg/kg/day p.o.) and colitis (10-50 mg/kg/day via i.p. or 1.25-6.25g/kg chow). |
| | N-(5-ADAMANTANE-1-YL-METHOXY)-PENTYL-DEOXYNOJIRIMYCIN Preparation Products And Raw materials |
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