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2-AG

2-AG Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:2-Arachidonoylglycerol
CAS:53847-30-6
Purity:95% Package:1mg;118USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:2-Arachidonoylglycerol
CAS:53847-30-6
Purity:98% Package:5mg Remarks:V5397
Company Name: Hangzhou MolCore BioPharmatech Co.,Ltd.
Tel: +86-057181025280; +8617767106207
Email: sales@molcore.com
Products Intro: Product Name:2-Arachidonoylglycerol
CAS:53847-30-6
Purity:NLT 98% Remarks:MC559203
Company Name: TargetMol Chemicals Inc.
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Email: support@targetmol.com
Products Intro: Product Name:2-Arachidonoylglycerol
CAS:53847-30-6
Purity:95% Package:1mg;118USD
Company Name: GIHI CHEMICALS CO.,LIMITED
Tel: +8618058761490
Email: info@gihichemicals.com
Products Intro: Product Name:2-arachidonyl Glycerol
CAS:53847-30-6
Purity:99 Package:5KG;1KG,25kg

2-AG manufacturers

2-AG Basic information
Product Name:2-AG
Synonyms:5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID, 2-GLYCERYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENOIC ACID, 2-HYDROXY-1-(HYDROXYMETHYL)ETHYL ESTER;2-AG;NOLADIN;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoicacid;2-Hydroxy-1-(hydroxymethyl)ethylester;1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate;2-Ara-gl
CAS:53847-30-6
MF:C23H38O4
MW:378.55
EINECS:200-835-2
Product Categories:Cannabinoid;Fatty Acid Derivatives & Lipids;Glycerols;Intermediates & Fine Chemicals;Pharmaceuticals;Cannabinoid receptor
Mol File:53847-30-6.mol
2-AG Structure
2-AG Chemical Properties
Boiling point 508.6±50.0 °C(Predicted)
density 0.992±0.06 g/cm3(Predicted)
Fp 2 °C
storage temp. -20°C
solubility DMSO: 10 mg/ml; Ethanol: Miscible; PBS (pH 7.2): ~150 μg/ml
form acetonitrile solution
pka13.54±0.10(Predicted)
color Colorless to light yellow
CAS DataBase Reference53847-30-6(CAS DataBase Reference)
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20/21/22-36
Safety Statements 26-36/37-16
RIDADR UN 1648 3/PG 2
WGK Germany 2
MSDS Information
ProviderLanguage
SigmaAldrich English
2-AG Usage And Synthesis
Uses2-Arachidonoylglycerol is a major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. It plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.
DefinitionChEBI: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
General Description2-Arachidonoylglycerol (2-AG), is an endocannabinoid, an endogenous agonist of the CB1 receptor. 2-AG, unlike anandamide, is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in mouse and rat brain (~5-10 nmol/g tissue). Detection of 2-AG in brain tissue is complicated by the relative ease of its isomerization to 1-AG during standard lipid extraction conditions. Unlike anandamide, formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol lipase (DAGL). 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is hydrolyzed in vitro by monoacylglycerol lipase (MAGL), fatty acid amide hydrolase (FAAH), and the uncharacterized serine hydrolase enzymes ABHD6 and ABHD12.
Biological ActivityEndogenous cannabinoid ligand that acts as a potent agonist at GPR55 (EC 50 values are 3, 519 and 618 nM at GPR55, CB 1 and CB 2 respectively; K i values are 472 and 1400 nM at CB 1 and CB 2 respectively). Found in the brain at concentrations 1000-fold higher than that of anandamide.
Biochem/physiol ActionsEndogenous cannabinoid receptor agonist.
Enzyme inhibitorThis potent endocannabinoid (FW = 378.30 g/mol; CAS 53847-30-6; Symbol: 2-AG), also known as 1,3-dihydroxy-2-propanyl (5Z,8Z,11Z,14Z)- 5,8,11,14-eicosatetraenoate, is an endogenous agonist of the CB1, the G- protein-coupled Cannabinoid receptor type-1 found primarily in the central and peripheral nervous system. 2-AG is found at highest concentrations in the CNS, where it exerts its cannabinoid-like neuromodulatory effects. Found in milk, 2-AG plays a role in sustaining infant suckling, and the selective CB1 receptor antagonist SR141617A (N-(piperidin-1-yl)-5-(4- chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3- carboxamide) permanently prevents milk ingestion in a dose-dependent manner, when administered to mouse pups, within 1 day of birth. 2-AG is formed by phospholipase C (PLC) and diacylglycerol lipase (DAGL) from arachidonic acid-containing diacylglycerol (DAG). In the CNS, three serine-hydrolases, monoacylglycerol lipase (MAGL), a,b-hydrolase- domain-6 (ABHD6) and a,b-hydrolase-domain 12 (ABHD12) are responsible for inactivation of the primary 2-arachidonoylglycerol. Irreversible ABHD6 inhibitors show exceptional potency and selectivity in cells (<5 nM) and, at equivalent doses in mice (1 mg/kg), acting as systemic and peripherally restricted inhibitors, respectively. Indeed, selective knockdown of ABHD6 in metabolic tissues protects mice from high-fat-diet-induced obesity, hepatic steatosis, and systemic insulin resistance.
storageStore at -80°C
Tag:2-AG(53847-30-6) Related Product Information
1-OCTADECANOYL-2-[(CIS,CIS,CIS,CIS)-5,8,11,14-EICOSATETRAENOYL]-SN-GLYCERO-3-PHOSPHOCHOLINE 1,2-DI5,8,11,14(ALL-CIS)EICOSATETRAENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE SPECS AG-205/15424553 1-AG 17-AAG SPECS AG-205/25005652 1-STEAROYL-2-ARACHIDONOYL-PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE, (NA+ SALT) 2-AG-D5 2-AG 1-O-HEXADECYL-2-ARACHIDONYL-SN-GLYCERO-3-PHOSPHOCHOLINE 1-STEAROYL-2-ARACHIDONOYL-SN-GLYCEROL 2-AG-D8 TRIARACHIDONIN SPECS AG-205/25006771 2-ARACHIDONYL GLYCEROL, [GLYCEROL 1,3-3H] PHOSPHATIDYLCHOLINE, L-ALPHA-1-O HEXADECYL-1-2-ARACHIDONYL, [ARACHIDONYL-5,6,8,9,11,12,14,15-3H(N)] PHOSPHATIDYLCHOLINE, L-ALPHA-1-PALMITOYL-, 2-ARACHIDONYL, [ARACHIDONYL-1-14C] PHOSPHATIDYLETHANOLAMINE, L-ALPHA-1-PALMITOYL, 2-ARACHIDONYL, [ARACHIDONYL-1-14C]

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