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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Neuronal Signaling >5-HT Receptor Antagonists >PRX-08066

PRX-08066

PRX-08066 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:PRX-08066 Maleic acid
CAS:866206-55-5
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:PRX-08066
CAS:866206-55-5
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Zhejiang J&C Biological Technology Co.,Limited
Tel: +1-2135480471 +1-2135480471
Email: sales@sarms4muscle.com
Products Intro: Product Name:PRX-08066
CAS:866206-55-5
Purity:99% Package:5KG;1KG Remarks:PRX-08066
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:PRX-08066 Maleic acid
CAS:866206-55-5
Purity:98% Package:5mg Remarks:V0969
Company Name: LEAP CHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:PRX-08066
CAS:866206-55-5
Package:1g; 5g; 25g; 1kg; 5kg; 25kg

PRX-08066 manufacturers

PRX-08066 Basic information
Product Name:PRX-08066
Synonyms:5-[[4-[(6-Chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile (2Z)-2-butenedioate (1:1);PRX-08066 Maleic acid;Benzonitrile, 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-, (2Z)-2-butenedioate (1:1);PRX-08066(96%);CS-2323;PRX-08066 USP/EP/BP;PRX-08066 (Maleate)
CAS:866206-55-5
MF:C23H21ClFN5O4S
MW:517.9603432
EINECS:
Product Categories:Inhibitors
Mol File:866206-55-5.mol
PRX-08066 Structure
PRX-08066 Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
Safety Information
MSDS Information
PRX-08066 Usage And Synthesis
UsesPRX-08066 Maleic acid is a selective 5-HT2BR antagonist. It has high selectivity over the closely related 5-HT2A and 5-HT2C receptors and other receptor targets.
Enzyme inhibitorThis selective 5-hydroxytryptamine (serotonin) receptor antagonist (FW = 517.96 g/mol; CAS = 866206-55-5), also named 5-((4-(6-chlorothieno[2,3- d]pyrimidin-4-ylamino)piperidin-1-yl)methyl)-2-fluorobenzonitrile, targets 5-HT2B (IC50 of 3.4 nM), showing high selectivity over the closely related 5-HT2A, 5-HT2C and other receptors and preventing the severity of pulmonary arterial hypertension in the monocrotaline (MCT)-induced rat pulmonary artery hypertension model. PRX-08066 significantly attenuates the elevation in pulmonary artery pressure and right ventricular hypertrophy, thereby improving cardiac function. Targeting the 5-5-HT2B receptor also appears be an effective antiproliferative and antifibrotic strategy for small intestinal neuroendocrine tumors (SI-NETs), because it inhibits tumor microenvironment fibroblasts as well as NET cells.
target5-HT2B
PRX-08066 Preparation Products And Raw materials
Tag:PRX-08066(866206-55-5) Related Product Information
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