J-147
| 中文名稱 | J-147 |
|---|---|
| 中文同義詞 | 2,2,2-三氟乙酸 1-(2,4-二甲基苯基)-2-[(3-甲氧基苯基)亞甲基]酰肼;化合物J147;J-147,神經(jīng)源性和神經(jīng)保護性姜黃素衍生物;N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE;化合物J147,10 MM DMSO 溶液;J147 J-147 CP級 99% 10G 100G 1KG |
| 英文名稱 | J 147 |
| 英文同義詞 | J147/J-147;2,2,2-Trifluoroacetic acid 1-(2,4-DiMethylphenyl)-2-[(3-Methoxyphenyl)Methylene]hydrazide;J 147;N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE;J 147 2,2,2-Trifluoroacetic acid 1-(2,4-dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide;Nootropic J147;CS-1446;J-147?, >98% |
| CAS號 | 1146963-51-0 |
| 分子式 | C18H17F3N2O2 |
| 分子量 | 350.33 |
| EINECS號 | 1592732-453-0 |
| 相關(guān)類別 | 抑制劑;小分子抑制劑;小分子抑制劑，天然產(chǎn)物;產(chǎn)品;Inhibitors;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol文件 | 1146963-51-0.mol |
| 結(jié)構(gòu)式 |  |
J-147 性質(zhì)
| 沸點 | 412.8±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.18±0.1 g/cm3(Predicted) |
| 儲存條件 | Sealed in dry,Room Temperature |
| 溶解度 | DMSO:68.0(最大濃度 mg/mL);194.1(最大濃度 mM) |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 0.80±0.50(Predicted) |
| 顏色 | 米白色至粉紅色 |
| InChI | InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3 |
| InChIKey | HYMZAYGFKNNHDN-UHFFFAOYSA-N |
| SMILES | C(N(C1=CC=C(C)C=C1C)N=CC1=CC=CC(OC)=C1)(=O)C(F)(F)F |
J-147 是一種特別有效的，具有口服活性的神經(jīng)保護劑，可增強認知能力。J-147 可透過血腦屏障 (BBB)。J-147 抑制單胺氧化酶 B (MAO B) 和多巴胺轉(zhuǎn)運體 (dopamine transporter)，EC50 分別為 1.88 μM 和 0.649 μM。J-147 有潛力用于阿爾茨海默氏癥 (AD) 的研究。
MAO B; Dopamine transporter
J-147 promotes HT22 and primary cell survival in a dose-dependent manner (EC 50 value range of 0.06-0.115 μM) .
J-147 (diet is prepared by the addition of J-147 at 200ppm; 6 months) enhances memory and dendritic spine number in old mice.
The half life (t
1/2
) of J-147 is calculated at 1.5 hrs in plasma and 2.5 hrs in brain ( per oral (PO) administration at a single dose of 20 mg/kg).
| Animal Model: | 24 male C57Bl/6 mice aged 24 months; using 8 month-old mice as controls |
| Dosage: | 200 ppm |
| Administration: | The diet was prepared by the addition of 200ppm; 6 months |
| Result: | While both young and old animals recognized when an object was moved a large distance (135 degrees), a reduction in the recognition index (RI) in aged mice was observed when the object was moved a smaller distance of 45 degrees. The reduction in the RI was reversed upon treatment with J147. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 10mM * 1mLin DMSO | 385元 |
| 2025/05/22 | HY-13779 | N-(2,4-DIMETHYLPHENYL)-N'-(3-METHOXYBENZYLIDENE)ACETOHYDRAZIDE J-147 | 1146963-51-0 | 5mg | 500元 |