Iodophenpropit dihydrobromide
| 中文名稱 | Iodophenpropit dihydrobromide |
|---|---|
| 中文同義詞 | 化合物 T15590;化合物 IODOPHENPROPIT DIHYDROBROMIDE |
| 英文名稱 | Iodophenpropit dihydrobromide |
| 英文同義詞 | Iodophenpropit hydrobromide |
| CAS號 | 145196-87-8 |
| 分子式 | C15H20BrIN4S |
| 分子量 | 495.22 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 145196-87-8.mol |
| 結(jié)構(gòu)式 |  |
Iodophenpropit dihydrobromide 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | DMSO:50.0(最大濃度 mg/mL);86.79(最大濃度 mM) 水:32.2(最大濃度 mg/mL);55.89(最大濃度 mM) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Soluble to 25 mM in water |
Iodophenpropit dihydrobromide 是一種有效的選擇性組胺 H3 受體 (histamine H3 receptor) 拮抗劑。[125I] Iodophenpropit 結(jié)合 H3 受體具有選擇性，可飽和，易于可逆，及高親和力 (KD 為 0.32 nM)。
|
H 3 Receptor 0.32 nM (Kd) |
Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor.
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC
50
of 1.57±0.3 μM.
Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits.
| Animal Model: | New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg |
| Dosage: | 1 μg/kg |
| Administration: | Administered through intramuscular (i.m.); b.i.d.; for 10 days |
| Result: | Could influence a detectable antibody response to SRBC. |