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Yichang Zhongyitai Trading Co., Ltd.
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Product Name:14,15-Epoxy-5(Z),8(Z),11(Z),17(Z)-Eicosatetraenoic acid
CAS:131339-24-7
Purity:98+% Package:100ug
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| Company Name: |
Alfa Chemistry
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1-516-6625404 |
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| Products Intro: |
Product Name:14,15-epoxy-5(Z),8(Z),11(Z),17(Z)-eicosatetraenoic acid
CAS:131339-24-7
Purity:90%+ Package:1g;10g;100g;1KG;5KG
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| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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400-9205774 |
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| Products Intro: |
Product Name:(±)14(15)-EpETE
CAS:131339-24-7
Purity:>98% Package:1mg;10mg;50mg;100mg;
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(+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID manufacturers
- (±)14(15)-EpETE
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- $0.00 / 25μg
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2025-05-01
- CAS:131339-24-7
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | (+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID Basic information |
| Product Name: | (+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID | | Synonyms: | 14,15-EPOXY EICOSATETRAENOIC ACID;(+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID;14(15)-EPETE;RGZIXZYRGZWDMI-IXQKDQKQSA-N;5,8,11-Tridecatrienoic acid, 13-[(2R,3S)-3-(2Z)-2-penten-1-yl-2-oxiranyl]-, (5Z,8Z,11Z)-rel-;()14(15)-EpETE(solution in ethanol) | | CAS: | 131339-24-7 | | MF: | C20H30O3 | | MW: | 318.45 | | EINECS: | | | Product Categories: | | | Mol File: | 131339-24-7.mol |  |
| | (+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID Chemical Properties |
| solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 1 mg/ml |
| | (+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID Usage And Synthesis |
| Description | EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.1,2 Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids, produces epoxides such as (±)14(15)-EpETrE which are prime candidates for the actual active mediator.3 However, the CYP450 metabolites of eicosapentaenoic acid (EPA; ) and docosahexaenoic acid (DHA; ) have been little studied relative to arachidonate epoxygenase metabolites. (±)14(15)-EpETE is the ω-3 homolog of 14(15)-EpETrE, derived via epoxidation of the 14,15-double bond of EPA. The EDHF activity of (±)14(15)-EpETE has not yet been determined. | | Uses | 14(15)-EpETE is the epoxide of cytochrome P450 (CYP450) and is involved in the regulation of vascular tone and renal function[1]. | | References | 1. Chataigneau, T., Félétou, M., Duhault, J., et al. Epoxyeicosatrienoic acids, potassium channel blockers, and endothelium-dependent hyperpolarization in the guinea-pig carotid artery Br. J. Pharmacol. 123(3),574-580(1998).
2. Fisslthaler, B., Popp, R., Kiss, L., et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries Nature 401(6752),493-497(1999).
3. Baron, A., Frieden, M., and Bény, J.L. Epoxyeicosatrienoic acids activate a high-conductance, Ca2+-dependent K+ channel on pig coronary artery endothelial cells J. Physiol. 504(Pt 3),537-543(1997). |
| | (+/-)14(15)-EPOXY-5Z,8Z,11Z,17Z-EICOSATETRAENOIC ACID Preparation Products And Raw materials |
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