小豆蔻明
| 中文名稱 | 小豆蔻明 |
|---|---|
| 中文同義詞 | 小豆蔻明;(E)-1-(2,4-二羥基-6-甲氧基苯基)-3-苯基丙-2-烯-1-酮;小豆蔻明、豆蔻素、小豆蔻查耳酮;豆寇明(小豆蔻明,豆蔻素,小豆蔻查耳酮);豆蔻素、小豆蔻查耳酮;豆寇明;CARDAMONIN 小豆蔻明;豆寇明(小豆蔻明 |
| 英文名稱 | CARDAMONIN |
| 英文同義詞 | Alpinetin chalcone;Chalcone, 2', 4'-dihydroxy-6'-methoxy-;(E)-2',4'-Dihydroxy-6'-methoxychalcone;(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenylprop-2-en-1-one;(E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one;2-Propen-1-one, 1-(2,4-dihydroxy-6-methoxyphenyl)-3-phenyl-, (2E)-;CARDAMONIN(RG);(2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one |
| CAS號 | 19309-14-9 |
| 分子式 | C16H14O4 |
| 分子量 | 270.28 |
| EINECS號 | |
| 相關(guān)類別 | 小分子抑制劑，天然產(chǎn)物;植物提取物;對照品;小分子抑制劑;中藥對照品;標(biāo)準(zhǔn)品;對照品-中藥對照品;查爾酮;Chalcones;Inhibitors;標(biāo)準(zhǔn)品 -中藥標(biāo)準(zhǔn)品;分析試劑-對照品;標(biāo)準(zhǔn)品，對照品 |
| Mol文件 | 19309-14-9.mol |
| 結(jié)構(gòu)式 |  |
小豆蔻明 性質(zhì)
| 熔點(diǎn) | 199～200℃ |
|---|---|
| 沸點(diǎn) | 484.5±45.0 °C(Predicted) |
| 密度 | 1.282±0.06 g/cm3(Predicted) |
| 儲存條件 | room temp |
| 溶解度 | 二甲基亞砜：≥20mg/mL |
| 酸度系數(shù)(pKa) | 7.00±0.40(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 粘黃色 |
| 穩(wěn)定性 | DMSO或乙醇溶液可在-20°下穩(wěn)定儲存2周。 |
| Target | Value |
|
NF-κB
(Cell-free assay) | |
|
TRPA1
(Cell-free assay) | 454 nM |
(E)-Cardamonin ((E)-Cardamomin) selectively blocksTRPA1 activation (IC 50 =454 nM) while does not interact with TRPV1 nor TRPV4 channel. Docking analysis of cardamonin demonstrates a compatible interaction with A-967079-binding site of TRPA1. (E)-Cardamonin ((E)-Cardamomin) does not significantly reduce HEK293 cell viability, nor does it impair cardiomyocyte constriction. (E)-Cardamonin ((E)-Cardamomin) suppresses the expression of Tgase-2, cyclooxygenase-2 (COX-2), and p65 (nuclear factor-κB) in a concentration-dependent manner, and restores the expression of IκB in MG63 and Raw264.7 cells.
(E)-Cardamonin ((E)-Cardamomin) (3-30 mg/kg, orally administered) significantly inhibits PBQ-induced writhing. CDN also produces a significant, dose-dependent increase in the withdrawal response latencies in carrageenan-induced hyperalgesia.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-N1378 | 小豆蔻明 (E)-Cardamonin | 19309-14-9 | 5mg | 246元 |
| 2025/05/22 | HY-N1378 | 小豆蔻明 (E)-Cardamonin | 19309-14-9 | 10mM * 1mLin DMSO | 270元 |