N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽
中文名稱 | N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 |
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中文同義詞 | N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 100MG;N-[2-[[[3-(4-氯苯基)-2-丙烯-1-基]甲基氨基]甲基]苯基]-N-(2-羥基乙基)-4-甲氧基苯磺酰胺;N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽;CA2+/鈣調(diào)蛋白依賴性激酶Ⅱ(CA2+/CAM PKⅡ)競爭性抑制劑KN-3;N-[2-[[[3-(4-氯苯基)烯丙基](甲基)氨基]甲基]苯基]-N-(2-羥乙基)-4-甲氧基苯磺酰胺;神經(jīng)元CAMK-II抑制劑(KN-93);(E)-N-(2-(((3-(4-氯苯基)烯丙基)(甲基)氨基)甲基)苯基)-N-(2-羥乙基)-4-甲氧基苯磺酰胺;(BASE),KN-93游離態(tài),鹽酸鹽,磷酸鹽各形式均有 |
英文名稱 | KN-93 |
英文同義詞 | 2-[N-(2-HYDROXYETHYL)-N-(4-METHOXYBENZENESULFONYL)]AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE;METHOXYBENZENE-SULFONAMIDE;KN-93;KN-93, WATER-SOLUBLE;N-[2-[[[3-(4'-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4'-METHOXY-BENZENESULFONAMIDE PHOSPHATE;N-[2-[[[3-(4-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULPHONAMIDE;N-[2-N-4-CHLOROCINNAMYL-N-METHYLAMINOMETHYLPHENYL]-N-[2-HYDROXYETHYL]-4-METHOXYBENZENESULFONAMIDE;KN-93,98% |
CAS號 | 139298-40-1 |
分子式 | C26H29ClN2O4S |
分子量 | 501.04 |
EINECS號 | |
相關(guān)類別 | 細(xì)胞生物學(xué)試劑;小分子抑制劑,天然產(chǎn)物;小分子抑制劑;試劑盒-細(xì)胞分析試劑盒;Inhibitors;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Protein Kinase |
Mol文件 | 139298-40-1.mol |
結(jié)構(gòu)式 |
N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 性質(zhì)
密度 | 1.288 |
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儲存條件 | 2-8°C |
溶解度 | 在DMSO中的溶解度為1 毫克/毫升 |
形態(tài) | 類白色固體 |
顏色 | 白色 |
InChIKey | LLLQTDSSHZREGW-AATRIKPKSA-N |
CAS 數(shù)據(jù)庫 | 139298-40-1(CAS DataBase Reference) |
Target | Value |
CaMKII
(Cell-free assay) | 2.58 μM(Ki) |
After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells.
KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina.
安全信息
危險品標(biāo)志 | Xn |
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危險類別碼 | 20/21/22 |
安全說明 | 22-24/25-36/37 |
WGK Germany | 3 |
海關(guān)編碼 | 29299000 |
提供商 | 語言 |
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更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2024/11/08 | S6787 | N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 KN-93 | 139298-40-1 | 5mg | 1176.13元 |
2024/11/08 | S6787 | KN-93 | 139298-40-1 | 10mM (1mL in DMSO) | 1531.53元 |