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N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽

N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽

中文名稱N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽
中文同義詞N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 100MG;N-[2-[[[3-(4-氯苯基)-2-丙烯-1-基]甲基氨基]甲基]苯基]-N-(2-羥基乙基)-4-甲氧基苯磺酰胺;N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽;CA2+/鈣調(diào)蛋白依賴性激酶Ⅱ(CA2+/CAM PKⅡ)競爭性抑制劑KN-3;N-[2-[[[3-(4-氯苯基)烯丙基](甲基)氨基]甲基]苯基]-N-(2-羥乙基)-4-甲氧基苯磺酰胺;神經(jīng)元CAMK-II抑制劑(KN-93);(E)-N-(2-(((3-(4-氯苯基)烯丙基)(甲基)氨基)甲基)苯基)-N-(2-羥乙基)-4-甲氧基苯磺酰胺;(BASE),KN-93游離態(tài),鹽酸鹽,磷酸鹽各形式均有
英文名稱KN-93
英文同義詞2-[N-(2-HYDROXYETHYL)-N-(4-METHOXYBENZENESULFONYL)]AMINO-N-(4-CHLOROCINNAMYL)-N-METHYLBENZYLAMINE;METHOXYBENZENE-SULFONAMIDE;KN-93;KN-93, WATER-SOLUBLE;N-[2-[[[3-(4'-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4'-METHOXY-BENZENESULFONAMIDE PHOSPHATE;N-[2-[[[3-(4-CHLOROPHENYL)-2-PROPENYL]METHYLAMINO]METHYL]PHENYL]-N-(2-HYDROXYETHYL)-4-METHOXYBENZENESULPHONAMIDE;N-[2-N-4-CHLOROCINNAMYL-N-METHYLAMINOMETHYLPHENYL]-N-[2-HYDROXYETHYL]-4-METHOXYBENZENESULFONAMIDE;KN-93,98%
CAS號139298-40-1
分子式C26H29ClN2O4S
分子量501.04
EINECS號
相關(guān)類別細(xì)胞生物學(xué)試劑;小分子抑制劑,天然產(chǎn)物;小分子抑制劑;試劑盒-細(xì)胞分析試劑盒;Inhibitors;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Protein Kinase
Mol文件139298-40-1.mol
結(jié)構(gòu)式N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 結(jié)構(gòu)式

N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 性質(zhì)

密度1.288
儲存條件2-8°C
溶解度在DMSO中的溶解度為1 毫克/毫升
形態(tài)類白色固體
顏色白色
InChIKeyLLLQTDSSHZREGW-AATRIKPKSA-N
CAS 數(shù)據(jù)庫139298-40-1(CAS DataBase Reference)

N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 用途與合成方法

KN-93 是一種具有細(xì)胞滲透性和競爭性的 Ca2+/calmodulin-dependent protein kinase II (CaMK-II) 的可逆抑制劑,對于兔心肌 CaM 激酶活性的Ki值為2.58 μM。
TargetValue
CaMKII
(Cell-free assay)
2.58 μM(Ki)

After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts. KN-93 inhibits the H + , K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93. KN-93 (10 μM )significantly inhibits the activation of CaMKII/NF-κB signaling induced by elevated glucose, and subsequently decreases the expression of VEGF, iNOS and ICAM-1 in Müller cells.

KN-93 (1 mg/kg/day, i.p.) inhibits retinal vascular leakage induced by diabetes, and suppresses phosphorylation of CaMKII and NF-κB in diabetic retina.

安全信息

危險品標(biāo)志Xn
危險類別碼20/21/22
安全說明22-24/25-36/37
WGK Germany3
海關(guān)編碼29299000

MSDS信息

提供商 語言
英文
英文
更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08S6787N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽
KN-93
139298-40-15mg1176.13元
2024/11/08S6787KN-93139298-40-110mM (1mL in DMSO)1531.53元

N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽 上下游產(chǎn)品信息

"N-[2-[N-(4-氯肉桂)-N-甲基氨基]苯基]-N-(2-羥乙基)-4-甲氧苯磺酰胺磷酸酯鹽"相關(guān)產(chǎn)品信息
N-甲基苯胺 N-甲基-2-羥基乙胺 N-甲基吡咯 N-甲基苯甲酰胺 N-甲基二乙醇胺
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