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反苯環(huán)丙胺半硫酸鹽

反苯環(huán)丙胺半硫酸鹽

中文名稱反苯環(huán)丙胺半硫酸鹽
中文同義詞反苯環(huán)丙胺半硫酸鹽;反式-2-苯基環(huán)丙胺 半硫酸鹽;反-2-苯基環(huán)丙基胺半硫酸鹽;硫酸反苯環(huán)丙胺 標準品;TRANYLCYPROMINE硫酸鹽;硫酸反苯環(huán)丙明;反-2-苯基環(huán)丙基胺半硫酸鹽(冷庫);TRANYLCYPROMINE SULFATE|||TRANYLCYPROMINE (HEMISULFATE)|||反苯環(huán)丙胺半硫酸鹽
英文名稱Tranylcypromine Hemisulfate
英文同義詞tranylcyprominesulfate;tranylcyprominesulphate;Tranylcypromine Sulfate (125 mg);(1R,2S)-rel-2-Phenylcyclopropanamine Sulfate;TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE;TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT;TRANYLCYPROMINE HEMISULFATE;TRANYLCYPROMINE HEMISULFATE SALT
CAS號13492-01-8
分子式C9H13NO4S
分子量231.27
EINECS號236-807-1
相關類別;原料藥
Mol文件13492-01-8.mol
結構式反苯環(huán)丙胺半硫酸鹽 結構式

反苯環(huán)丙胺半硫酸鹽 性質(zhì)

儲存條件15-25°C
溶解度易溶于水;極微溶于乙醇(96%)和乙醚。
形態(tài)白色固體。
顏色白色
水溶解性water: 0.0333g/mL, clear to slightly hazy, colorless to faintly yellow
穩(wěn)定性自購買之日起 1 年內(nèi)保持穩(wěn)定。蒸餾水溶液可在 -20° 下保存長達 3 個月。
InChIKeyBKPRVQDIOGQWTG-FKXFVUDVSA-N

反苯環(huán)丙胺半硫酸鹽 用途與合成方法

Tranylcypromine (Parnate)是不可逆型單胺氧化酶 (MAO)抑制劑。

Tranylcypromine (10 nM to 10 μM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity.

Tranylcypromine treatment significantly and substantially reduces the lesion size and improves generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, tranylcypromine treatment results in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT and lesion growth. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 μg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry. Tranylcypromine causes the greatest increase in cell proliferation in the cerebellum.

安全信息

危險品標志T
危險類別碼23/24/25
安全說明36/37/39-45
危險品運輸編號UN 2811 6.1/PG 2
WGK Germany3
RTECS號GZ2625000
危險等級6.1(b)
包裝類別III
海關編碼2921490002

MSDS信息

提供商 語言
英文
更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2025/02/08HY-B1496反苯環(huán)丙胺半硫酸鹽
Tranylcypromine hemisulfate
13492-01-8100mg500元
2025/02/08XW134921802試劑Tranylcypromine hemisulfate
Tranylcypromine hemisulfate
250mg186元

反苯環(huán)丙胺半硫酸鹽 上下游產(chǎn)品信息

"反苯環(huán)丙胺半硫酸鹽"相關產(chǎn)品信息
ML324 1-苯?;?3-苯基硫脲 4-苯基丁酸鈉鹽 N,N'-[磺酰基二(4,1-亞苯基)]二(2-氯乙酰胺) 反苯環(huán)丙胺鹽酸鹽 環(huán)丙基苯 反-2-苯基環(huán)丙胺 硫酸苯丙胺 環(huán)丙胺 反苯環(huán)丙胺半硫酸鹽
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