反苯環(huán)丙胺半硫酸鹽
中文名稱 | 反苯環(huán)丙胺半硫酸鹽 |
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中文同義詞 | 反苯環(huán)丙胺半硫酸鹽;反式-2-苯基環(huán)丙胺 半硫酸鹽;反-2-苯基環(huán)丙基胺半硫酸鹽;硫酸反苯環(huán)丙胺 標準品;TRANYLCYPROMINE硫酸鹽;硫酸反苯環(huán)丙明;反-2-苯基環(huán)丙基胺半硫酸鹽(冷庫);TRANYLCYPROMINE SULFATE|||TRANYLCYPROMINE (HEMISULFATE)|||反苯環(huán)丙胺半硫酸鹽 |
英文名稱 | Tranylcypromine Hemisulfate |
英文同義詞 | tranylcyprominesulfate;tranylcyprominesulphate;Tranylcypromine Sulfate (125 mg);(1R,2S)-rel-2-Phenylcyclopropanamine Sulfate;TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE;TRANS-2-PHENYLCYCLOPROPYLAMINE HEMISULFATE SALT;TRANYLCYPROMINE HEMISULFATE;TRANYLCYPROMINE HEMISULFATE SALT |
CAS號 | 13492-01-8 |
分子式 | C9H13NO4S |
分子量 | 231.27 |
EINECS號 | 236-807-1 |
相關類別 | 胺;原料藥 |
Mol文件 | 13492-01-8.mol |
結構式 | ![]() |
反苯環(huán)丙胺半硫酸鹽 性質(zhì)
儲存條件 | 15-25°C |
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溶解度 | 易溶于水;極微溶于乙醇(96%)和乙醚。 |
形態(tài) | 白色固體。 |
顏色 | 白色 |
水溶解性 | water: 0.0333g/mL, clear to slightly hazy, colorless to faintly yellow |
穩(wěn)定性 | 自購買之日起 1 年內(nèi)保持穩(wěn)定。蒸餾水溶液可在 -20° 下保存長達 3 個月。 |
InChIKey | BKPRVQDIOGQWTG-FKXFVUDVSA-N |
Tranylcypromine (10 nM to 10 μM) exerts neuroprotective effects against toxicity induced by human Aβ(1-42) oligomers independently from the presence of glial cells. Tranylcypromine (100 μM) significantly protects RGCs from glutamate neurotoxicity-induced apoptosis as well as apoptosis induced by oxidative stress. Tranylcypromine promotes mitogen-activated protein kinase 12 (p38 MAPKγ) expression under conditions of glutamate (Glu)-induced stress. Besides, tranylcypromine contributes to RGC survival via alterations of p38 MAPKγ activity.
Tranylcypromine treatment significantly and substantially reduces the lesion size and improves generalized hyperalgesia in a dose-dependent fashion in mice with induced endometriosis. In addition, tranylcypromine treatment results in reduced immunoreactivity to biomarkers of proliferation, angiogenesis, and H3K4 methylation, leading to arrested EMT and lesion growth. Tranylcypromine (500 mM) injection exerts neuroprotective effects within intracellular apoptotic signaling pathways and suppresses morphologic changes in the retina of the rat, suppresses caspase 3 activity and recovers p38 MAPKγ expression in the retina after NMDA-induced injury, and enhances RGC survival after retinal injury via the attenuation of NMDA neurotoxicity. Tranylcypromine (10 μg/g) causes an approximate and significant doubling of labeled cells in the combined brain regions examined, as detected by BrdU immunohistochemistry. Tranylcypromine causes the greatest increase in cell proliferation in the cerebellum.
安全信息
危險品標志 | T |
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危險類別碼 | 23/24/25 |
安全說明 | 36/37/39-45 |
危險品運輸編號 | UN 2811 6.1/PG 2 |
WGK Germany | 3 |
RTECS號 | GZ2625000 |
危險等級 | 6.1(b) |
包裝類別 | III |
海關編碼 | 2921490002 |
提供商 | 語言 |
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英文
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更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
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2025/02/08 | HY-B1496 | 反苯環(huán)丙胺半硫酸鹽 Tranylcypromine hemisulfate | 13492-01-8 | 100mg | 500元 |
2025/02/08 | XW134921802 | 試劑Tranylcypromine hemisulfate Tranylcypromine hemisulfate | 250mg | 186元 |