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ChemicalBook > Product Catalog >API >Antineoplastic agents >Antibiotics anticancer drugs >PEPLOMYCIN

PEPLOMYCIN

PEPLOMYCIN Suppliers list
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:PEPLOMYCIN
CAS:68247-85-8
Purity:99.9% Package:1g;1.1USD Remarks:FDA GMP CEP Approved Manufacturer
Company Name: XIAMEN AMITY INDUSTRY AND TRADE CO., LTD.
Tel: +8618950047208
Email: ellena@amitychem.com
Products Intro: Product Name:Bleomycin PEP
CAS:68247-85-8
Purity:99.99% Package:25kg/drum
Company Name: Baoji Didu Pharmaceutical and Chemical Co., Ltd  
Tel: 029-02961856358 15829236573
Email: 1035@dideu.com
Products Intro: Product Name:PEPLOMYCIN
CAS:68247-85-8
Purity:98% Package:25KG
Company Name: CUSABIO TECHNOLOGY LLC  
Tel: 027-87196173
Email: cusabio@163.com
Products Intro: Product Name:FXYD1
Company Name: Merck KGaA  
Tel: 21-20338288
Email: ordercn@merckgroup.com
Products Intro: Product Name:MONOCLONAL ANTI-PHOSPHO-PLM(S68) antibody produced in mouse

PEPLOMYCIN manufacturers

  • PEPLOMYCIN USP/EP/BP
  • PEPLOMYCIN USP/EP/BP pictures
  • $1.10 / 1g
  • 2021-07-02
  • CAS:68247-85-8
  • Min. Order: 1g
  • Purity: 99.9%
  • Supply Ability: 100 Tons Min
PEPLOMYCIN Basic information
Product Name:PEPLOMYCIN
Synonyms:PEPLOMYCIN;Bleomycin PEP;NK-631{PEP;Pelomecin Sulfate:Pepleo Injection;PEP-Bleomycin;Pepleocine;Peplocin;Pepreomycin
CAS:68247-85-8
MF:C61H88N18O21S2
MW:1473.59
EINECS:269-484-0
Product Categories:
Mol File:68247-85-8.mol
PEPLOMYCIN Structure
PEPLOMYCIN Chemical Properties
density 1.0908 (rough estimate)
refractive index 1.6700 (estimate)
storage temp. -20°C
form buffered aqueous solution
biological sourcemouse
Safety Information
MSDS Information
PEPLOMYCIN Usage And Synthesis
OriginatorPepleo, Nippon Kayaku, Co., Japan ,1981
UsesAntineoplastic.
DefinitionChEBI: Peplomycin is a glycopeptide.
Manufacturing ProcessIn 400 ml of dimethylformamide was dissolved 15.0 g of bleomycinic acid (copper-containing form). To the solution kept at 0°C by cooling were added 1.1 ml of N-methylmorpholine and 10.3 g of 6-chloro-1-pchlorobenzenesulfonyloxybenzotriazole (CCBT) as an activating compound. The mixture was stirred for 5 minutes at 0°C, then admixed with 5.3 g of N[(S)-1'-phenylethyl]-1,3-diaminopropane and further stirred for 1 hour.
After termination of the reaction by adding 200 ml of a 25% aqueous acetic acid solution, the reaction mixture was mixed with 5 liters of cold acetone to precipitate the reaction product. The precipitate was collected by filtration, washed with acetone, and dissolved in 500 ml of distilled water. The resulting aqueous solution was immediately adjusted to pH 6.0 and poured into a column containing 2 liters of CM-Sephadex C-25 (NH4+type) packed in 0.05 M aqueous ammonium chloride solution to adsorb bleomycins.
Using aqueous ammonium chloride solution, elution was performed by passing through the column 20 liters of eluent in which the concentration of ammonium chloride was continually increased from 0.05 to 1.0 M. The unreacted bleomycinic acid was found in the effluent at the ammonium chloride concentration of about 0.05 M and NK631 at the ammonium chloride concentration of about 0.45 M. Both fractions, which showed UV absorption at 292 nm;, were separately collected.
The NK631-containing fraction was poured into a resin column containing 2.6 liters of Amberlite XAD-2. The column was then washed thoroughly with water and eluted with 0.01 N hydrochloric acid in methanol-water (4:1 v/v). A total of 2.5 liters of the blue fraction, which showed UV absorption at 292 mμ, was collected. After evaporating off the methanol from the eluent fraction, the concentrate was adjusted to pH 6.0 with Dowex 44 (OH- type, an anionexchange resin composed of a copolymer of epichlorohydrin and ammonia) and was freeze-dried to obtain 16.1 g (92% yield) of NK631 dihydrochloride (copper-containing form) in the form of blue amorphous powder.
By similar treatment, 280 mg of the unreacted bleomycinic acid (coppercontaining form) were recovered.
In 200 ml of distilled water was dissolved 10.0 g of the NK631 dihydrochloride (copper-containing form). The solution was poured into a column containing 600 ml of Amberlite XAD-2 packed in distilled water. The column was washed successively with 2 liters of an aqueous solution containing 5% of EDTA-Na2, 2.5 liters of a 5% aqueous sodium sulfate solution, and 630 ml of distilled water.
The column was then eluted with 0.0025 N sulfuric acid in methanol-water mixture (1:1 v/v). A total of 900 ml of fractions containing a substance which showed UV absorption at 290 mμ was collected. After removal of methanol by distillation, the residual liquid was adjusted to pH 6.0 with Dowex 44 (OHtype) and freeze-dried to obtain 9.3 g (95% yield) of NK631 monosulfate (copper-free form) in the form of pale yellowish-white amorphous powder.
Therapeutic FunctionAntineoplastic
Tag:PEPLOMYCIN(68247-85-8) Related Product Information
Bleomycin Natamycin PEPLOMYCIN SULFATE 2-Methylpyrimidine-4-carboxaldehyde 2-THIAZOL-2-YL-ETHYLAMINE HCL HYDROXYPROPYLCARBAMATE 4-Pyrimidinecarboxamide,6-amino- 4(5)-(2-amino-1-hydroxyethyl)imidazole 4-Pyrimidinecarboxamide,2-methyl- 2-(4-METHYL-1,3-THIAZOL-2-YL)ETHANAMINE 2-[2-(3-aminopropoxy)ethoxy]ethanol 1-METHYL-1,2,3,4-TETRAHYDRO-QUINOLINE-6-CARBOXYLIC ACID 4-Pyrimidinemethanamine, N-methyl- (9CI) hedonal 2-PYRIMIDINEMETHANAMINE PEPLOMYCIN

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