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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Suppliers list
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Products Intro: Product Name:Varenicline hydrochloride
CAS:230615-23-3
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Products Intro: Product Name:6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
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Products Intro: Product Name:6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride (Varenicline hydrochloride)
CAS:230615-23-3
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Products Intro: Product Name:Varenicline Hydrochloride
CAS:230615-23-3
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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride manufacturers

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Basic information
Product Name:6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
Synonyms:6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-,monohydrochloride (Varenicline Hcl);Varenicline hydrochloride;6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride;5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, hydrochloride (1:1);7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride;6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride
CAS:230615-23-3
MF:C13H14ClN3
MW:247.73
EINECS:
Product Categories:API intermediates
Mol File:230615-23-3.mol
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Structure
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Powder
color Light yellow to khaki
Safety Information
MSDS Information
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Usage And Synthesis
UsesVarenicline Hydrochloride is a useful nicotine binding inhibitor.
Biological Activityvarenicline hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].varenicline hydrochloride has been reported to potently inhibit nachr binding with the ki values of 0.12±0.02 nm and 0.14±0.01 nm for α6β2* nachr and α4β2* nachr, respectively in rat striatum, 0.13±0.01 nm and 0.19±0.11 nm forα6β2* nachr and α4β2* nachr, respectively in monkey striatum. in addition, varenicline hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nachrs compared with nicotine with the ec50 values of 0.007 and 0.086μm, respectively in rat striatum [1].
references[1] bordia t1, hrachova m, chin m, mcintosh jm, quik m. varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. j pharmacol exp ther. 2012 aug;342(2):327-34. doi: 10.1124/jpet.112.194852. epub 2012 may 1.
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Preparation Products And Raw materials
Tag:6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride(230615-23-3) Related Product Information
Varenicline-d4 Dihydrochloride (Major) Varenicline Lactam Varenicline N-Glucoside Varenicline Carbamoyl β-D-Glucuronide 6,7-DIMETHYLQUINOXALINE 10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Varenicline 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

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