鹽酸吐根酚堿
| 中文名稱 | 鹽酸吐根酚堿 |
|---|---|
| 中文同義詞 | 吐根酚堿鹽酸鹽 EP標(biāo)準(zhǔn)品;6-異喹啉,1-[(2S,3R,11BS)-3-乙基-1,3,4,6,7,11B-六羥基-9,10-二甲氧基-2H-苯并[A]喹硫萊胺-2-YL]甲基]-1,2,3,4-四氫-7-甲氧基-,鹽酸鹽(1:2),(1R)-;吐根酚堿鹽酸鹽(鹽酸吐根酚堿);(1R)-1-[[(2S,3R,11BS)-3-乙基-1,3,4,6,7,11B-六氫-9,10-二甲氧基-2H-苯并[A]喹嗪-2-基]甲基]-1,2,3,4-四氫-7-甲氧基-6-異喹啉醇二鹽酸鹽;吐根酚堿鹽酸鹽 EP |
| 英文名稱 | cephaeline hydrochloride |
| 英文同義詞 | cephaelin hydrochloride;Cephaeline dihydrochloride;(1R)-1-[[(2S,3R,11bS)-3-Ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-6-isoquinolinol hydrochloride;NSC 32944;Cephaeline HCl salt;(-)-CEPHAELINE DIHYDROCHLORIDE;Cephaeline hydrochloride CRS;Cephaeline DiHCl |
| CAS號 | 5853-29-2 |
| 分子式 | C28H39ClN2O4 |
| 分子量 | 503.08 |
| EINECS號 | 227-463-3 |
| 相關(guān)類別 | 對照品-中藥對照品;可定制;分析試劑標(biāo)準(zhǔn)品;對照品;雜質(zhì)對照品;中藥對照品 |
| Mol文件 | 5853-29-2.mol |
| 結(jié)構(gòu)式 |  |
鹽酸吐根酚堿 性質(zhì)
| 儲存條件 | 4°C, protect from light |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Cephaeline dihydrochloride 是選擇性的 CYP2D6 抑制劑，IC50 為 121 μM。
IC50: 121 μM (CYP2D6)
Ki: 54 μM (CYP2D6)
CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively.
化學(xué)性質(zhì)
類白至黃色粉末，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來源于吐根，安哥拉八角楓。用途
鹽酸吐根酚堿能殺滅溶織阿米巴滋養(yǎng)體，有毒。類別
有毒物質(zhì)毒性分級
高毒急性毒性
腹腔-大鼠 LD50: 10 毫克/公斤; 口服-小鼠 LD50: 74.97 毫克/公斤可燃性危險特性
熱分解排出有毒氮氧化物, 氯化氫煙霧儲運(yùn)特性
庫房低溫通風(fēng)干燥; 與食品原料分開存放滅火劑
水,二氧化碳, 泡沫, 干粉安全信息
| 危險品運(yùn)輸編號 | 1544 |
|---|---|
| 危險等級 | 6.1(b) |
| 包裝類別 | III |
| 毒性 | LD50 oral in mouse: 74970ug/kg |