異冬谷酸
| 中文名稱 | 異冬谷酸 |
|---|---|
| 中文同義詞 | 鹽酸索他洛爾-D6;N-乙?；?L-天冬氨酰-L-谷氨酸;異冬谷酸;(S)-2-((S)-2-乙酰氨基-3-羧基丙酰胺基)戊二酸;SPAGLUMIC ACID/異冬谷酸;AC-ASP-GLU-OH 化學(xué)試劑;AC-天冬氨酸-谷氨酸-OH;乙酰基-天冬氨酸-谷氨酸 |
| 英文名稱 | N-acetyl aspartyl-glutaMic acid |
| 英文同義詞 | SPAGLUMIC ACID;NAAG;N-ACETYL-L-ASPARTYL-L-GLUTAMIC ACID;N-ACETYLASPARTYLGLUTAMIC ACID;N-ACETYL-ASP-GLU;N-ACETYL-ASP-GLU-OH;ALPHA-NAAG;AC-ASP-GLU |
| CAS號 | 3106-85-2 |
| 分子式 | C11H16N2O8 |
| 分子量 | 304.25 |
| EINECS號 | 628-471-3 |
| 相關(guān)類別 | |
| Mol文件 | 3106-85-2.mol |
| 結(jié)構(gòu)式 |  |
異冬谷酸 性質(zhì)
| 熔點 | 171-173 °C |
|---|---|
| 沸點 | 769.5±60.0 °C(Predicted) |
| 密度 | 1.472±0.06 g/cm3(Predicted) |
| 儲存條件 | -20°C |
| 溶解度 | H2O:50 mg/mL |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 3.04±0.10(Predicted) |
| 顏色 | 白色 |
| 旋光性 (optical activity) | [α]22/D 34.5°, c = 1.1 in H2O(lit.) |
| 水溶解性 | Soluble to 100 mM in water |
| 穩(wěn)定性 | 吸濕性 |
Spaglumic Acid (N-Acetylaspartylglutamic acid) 是一種在腦中以毫摩爾濃度存在的神經(jīng)肽。
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Human Endogenous Metabolite
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Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca 2+ -dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders.
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