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Product Name:4-Deoxypyridoxine 5'-phosphate
CAS:883-84-1
Purity:>=98% Remarks:Reach out to us for more information about custom solutions.
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| | 4-DEOXYPYRIDOXINE 5-PHOSPHATE Basic information |
| Product Name: | 4-DEOXYPYRIDOXINE 5-PHOSPHATE | | Synonyms: | 4-DEOXYPYRIDOXINE 5-PHOSPHATE;(5-hydroxy-4,6-dimethyl-3-pyridyl)methyl dihydrogen phosphate;(5-hydroxy-4,6-dimethyl-pyridin-3-yl)methyl dihydrogen phosphate;(5-hydroxy-4,6-dimethylpyridin-3-yl)methyl dihydrogen phosphate;3-Pyridinemethanol, 5-hydroxy-4,6-dimethyl-, 3-(dihydrogen phosphate);4-Deoxypyridoxine Phosphate;4-Deoxypyridoxine 5'-phosphate | | CAS: | 883-84-1 | | MF: | C8H12NO5P | | MW: | 233.16 | | EINECS: | | | Product Categories: | | | Mol File: | 883-84-1.mol |  |
| | 4-DEOXYPYRIDOXINE 5-PHOSPHATE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Water: soluble | | form | A crystalline solid | | color | White to off-white | | Water Solubility | Water: soluble |
| | 4-DEOXYPYRIDOXINE 5-PHOSPHATE Usage And Synthesis |
| Uses | 4-Deoxypyridoxine 5'-phosphate is a Pyridoxal 5'-phosphate analogue and a sphingosine 1-phosphate (S1P) inhibitor. 4-Deoxypyridoxine 5'-phosphate inhibits ornithine decarboxylase activity with a Ki of 60 μM. 4-Deoxypyridoxine 5'-phosphate is a competitive inhibitor of the activation of glutamate apodecarboxylase by Pyridoxal 5'-phosphate (Ki of 0.27 μM) and strongly inhibits glutamate-dependent labeling of glutamate decarboxylase[1][2][3]. | | References | [1] Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. DOI:10.1007/s11745-016-4187-0
[2] M J Connor, et al. Epidermal Pyridoxal 5'-phosphate Depletion, Inhibition of DNA Synthesis, and Inhibition of the Expression of Ornithine Decarboxylase Activity by the Vitamin B-6 Antagonist 4'-deoxypyridoxine. J Invest Dermatol. 1983 Aug;81(2):136-9. DOI:10.1111/1523-1747.ep12543346
[3] D L Martin, et al. Glutamate-dependent Active-Site Labeling of Brain Glutamate Decarboxylase. J Neurochem. 1990 Aug;55(2):524-32. DOI:10.1111/j.1471-4159.1990.tb04166.x |
| | 4-DEOXYPYRIDOXINE 5-PHOSPHATE Preparation Products And Raw materials |
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