馬來酸哌克昔林
| 中文名稱 | 馬來酸哌克昔林 |
|---|---|
| 中文同義詞 | 馬來酸哌克昔林;馬來酸哌西林;2-(2,2-二環(huán)己基乙基)哌啶 馬來酸鹽;哌克昔林 馬來酸鹽;RAC 馬來酸哌克昔林;馬來酸哌克昔林,10 MM DMSO 溶液;肉堿棕櫚酰轉(zhuǎn)移酶1抑制劑(PERHEXILINE MALEATE);Perhexiline maleate試劑 |
| 英文名稱 | PERHEXILINE MALEATE SALT |
| 英文同義詞 | 2-(2,2-dicyclohexylethyl)piperidinemaleate;2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1);perhexilinemaleate;perhexilene maleate;Pexid;WSM-3978;rac Perhexiline Maleate;2-(2,2-dicyclohexylethyl)piperidinium hydrogen maleate |
| CAS號 | 6724-53-4 |
| 分子式 | C23H39NO4 |
| 分子量 | 393.56 |
| EINECS號 | 229-775-5 |
| 相關(guān)類別 | 細胞生物學(xué)試劑;醫(yī)藥原料;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;THENYLENE |
| Mol文件 | 6724-53-4.mol |
| 結(jié)構(gòu)式 |  |
馬來酸哌克昔林 性質(zhì)
| 熔點 | 181-183°C |
|---|---|
| 儲存條件 | 2-8°C |
| 溶解度 | 二甲基亞砜：≥5mg/mL |
| 形態(tài) | 粉末 |
| 顏色 | 白色至棕褐色 |
Perhexiline maleate 是一種有效的 carnitine palmitoyltransferase 1 (CPT1) 的抑制劑，對大鼠心臟CPT1和肝臟CPT1的IC50值分別為77 μM和148 μM。
| Target | Value |
|
rat heart CPT1
(Cell-free assay) | 77 μM |
|
rat liver CPT1
(Cell-free assay) | 148 μM |
At 24, 48 and 72?h of treatment with 0.01 and 1?μM of Perhexiline , NDM29 ncRNA expression level in SH-SY5Y cells is progressively increased, reaching a peak after 48?hours of treatment. Perhexiline treatment increases the susceptibility of NB cells to antiblastic treatments. Co-administration of Perhexiline maleate potentiates the efficacy of cisplatin to reduce the in vitro clonogenic potential of NB cells.
The co-administration of Perhexiline and cisplatin yields a clear enhancement of antitumor effects, resulting in a significantly improved progression-free survival as compared with mice treated with DMSO. Perhexiline favors NB cell transition to differentiated phenotype.
安全信息
| WGK Germany | 2 |
|---|---|
| RTECS號 | TM7068000 |
| 毒性 | LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri) |
| 提供商 | 語言 |
|---|---|
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英文
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