(E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺
| 中文名稱 | (E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺 |
|---|---|
| 中文同義詞 | (E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺;化合物SU1498;(E)-2-氰基-3-(4-羥基-3,5-二異丙基苯基)-N-(3-苯基丙基)丙烯酰胺;SU1498,VEGFR2抑制劑 |
| 英文名稱 | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide |
| 英文同義詞 | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropyl)acrylamide;(E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)-N-(3-phenylpropy;SU1498, >98%;Tyrphostin SU 1498, >98%;CS-1481;(E)-2-CYANO-3-(4-HYDROXY-3;5-DIISOPROPYLPHENYL)-N-(3-PHENYLPROPYL)ACRYLAMIDE;CHEMBL261508 |
| CAS號 | 168835-82-3 |
| 分子式 | C25H30N2O2 |
| 分子量 | 390.52 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 168835-82-3.mol |
| 結(jié)構(gòu)式 |  |
(E)-2-氰基-3-(4-羥基-3,5-二異丙苯基)-N-(3-苯基丙基)丙烯酰胺 性質(zhì)
| 熔點 | 126 °C |
|---|---|
| 沸點 | 590.6±50.0 °C(Predicted) |
| 密度 | 1.100±0.06 g/cm3(Predicted) |
| 儲存條件 | -20°C |
| 溶解度 | 溶于二甲基亞砜。 |
| 酸度系數(shù)(pKa) | 10.30±0.36(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| 穩(wěn)定性 | 自購買之日起 1 年內(nèi)保持穩(wěn)定。 DMSO 中的溶液可在 -20° 下保存長達(dá) 3 個月。 |
| CAS 數(shù)據(jù)庫 | 168835-82-3 |
| Target | Value |
|
KDR
() |
SU1498 stimulates accumulation of phosphorylated ERKs in human umbilical vein endothelial cells and in human aortic endothelial cells in a manner that is dependent on the functioning of the upstream components of the MAPK pathway, B-Raf, and MEK kinases. The enhanced accumulation of phospho-ERKs is observed only in cells that have been stimulated with sphingosine 1-phosphate or protein growth factors; SU1498 by itself is ineffective. SU1498 blocks signal transduction from VEGFR2 in MS1 VEGF cells.In the presence of SU1498, levels of Ets-1 are decreased, suggesting that VEGF-VEGFR-2 interactions contributed to baseline levels of Ets-1 expression, and interruption of this autocrine interaction with SU1498 led to decreased expression of Ets-1. SU1498 treatment significantly impacts U87 cell proliferation and apoptosis. SU1498 induces a marked increase in lipids and a decrease in glycerophosphocholine. Accordingly, accumulation of lipid droplets is seen in the cytoplasm of SU1498-treated U87 cells.
安全信息
| 海關(guān)編碼 | 2926.90.4801 |
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| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2024/11/08 | U0103 | SU 1498 SU 1498 | 168835-82-3 | 5mg | 220元 |
| 2024/11/08 | U0103 | SU 1498 SU 1498 | 168835-82-3 | 25mg | 1030元 |