鹽酸特拉唑嗪
| 中文名稱 | 鹽酸特拉唑嗪 |
|---|---|
| 中文同義詞 | 特拉唑嗪標準品2-R;鹽酸特拉唑嗪雜質(zhì)B;(R)-特拉唑嗪;(R)-特拉唑嗪,10 MM DMSO 溶液;(R)-(4-(4-氨基-6,7-二甲氧基喹唑啉-2-基)哌嗪-1-基)(四氫呋喃-2-基)甲酮 |
| 英文名稱 | (R)-Terazosin |
| 英文同義詞 | (R)-Terazosin;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(tetrahydro-2-furanyl)carbonyl]-, (R)-;Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[[(2R)-tetrahydro-2-furanyl]carbonyl]- (9CI);Terazosin-002-R;(R)-(4-(4-Amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(tetrahydrofuran-2-yl)methanone;Methanone, [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl][(2R)-tetrahydro-2-furanyl]-;(R)-Terazosin,α1-adrenoceptor,affinity,inhibit,subtypes,prove,Adrenergic Receptor,(R)Terazosin,Inhibitor,(R) Terazosin,Low,α2-adrenoceptor,Beta Receptor;(R)-Terazosin, 10 mM in DMSO |
| CAS號 | 109351-34-0 |
| 分子式 | C19H25N5O4 |
| 分子量 | 387.43 |
| EINECS號 | |
| 相關(guān)類別 | 對照品-雜質(zhì)對照品;雜質(zhì)對照品 |
| Mol文件 | 109351-34-0.mol |
| 結(jié)構(gòu)式 |  |
鹽酸特拉唑嗪 性質(zhì)
| 沸點 | 664.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.332±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 二甲基亞砜：75 mg/mL（193.58 mM） |
| 酸度系數(shù)(pKa) | 6.52±0.50(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
Ki: 6.51 nM (α1a-adrenoceptor), 1.01 nM (α1b-adrenoceptor) and 1.97 nM (α1d-adrenoceptor)
(R)-Terazosin is low affinity for α2a, α2B and α2c-adrenoceptor with K
i
values of 3.85 μM, 0.33 μM and 0.37 μM, respectively.
(R)-Terazosin may prove to be a useful probe in understanding the functional role of subtypes of adrenoceptors in various tissues. Because it is a weaker antagonist at α2B sites than its enantiomer, it may be possible to use (R)-Terazosin to differentiate between pharmacological effects mediated by subtypes of α2-adrenoceptors in animal studies.
(R)-Terazosin shows antagonism of at rat atrial α2B receptor with a pEC 30 of 5.69. (R)-Terazosin shows antagonism of at rat vas deferens α1A and α2A receptor with pA 2 values of 7.5 and 5.31, respectively.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2025/05/22 | HY-B0371B | 鹽酸特拉唑嗪 (R)-Terazosin | 109351-34-0 | 1 mg | 491元 |
| 2025/05/22 | HY-B0371B | 鹽酸特拉唑嗪 (R)-Terazosin | 109351-34-0 | 10mM * 1mLin DMSO | 1055元 |