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ChemicalBook > Product Catalog >Organic Chemistry >Phosphines >Risedronic acid

Risedronic acid

Risedronic acid Suppliers list
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Products Intro: Product Name:Risedronic acid
CAS:105462-24-6
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Products Intro: Product Name:1-Hydroxy-2-(3-pyridyl)-ethan-1,1-bis-phosphonic acid
CAS:105462-24-6
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Risedronic acid manufacturers

  • Risedronic acid
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  • 2025-07-04
  • CAS:105462-24-6
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  • Purity: 98.0%
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  • Risedronic acid
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  • 2025-06-27
  • CAS:105462-24-6
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  • Purity: 99%
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  • Risedronic Acid
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  • $68.00 / 100mg
  • 2025-06-22
  • CAS:105462-24-6
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  • Purity: 99.85%
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Risedronic acid Basic information
Product Name:Risedronic acid
Synonyms:1-Hydroxy-2-(3-pyridyl)-ethan-1,1-bis-phosphonic acid;RISEDRONIC ACID: RISEDRONIC ACID MONOHYDRATE;1-Hydroxy-2-(3-pyridinyl)ethylidenebisphosphonicacidmonohydrate;1-HYDROXY-2-(3-PYRIDINYL)ETHYLIDENE]BISPHOSPHONIC ACID;3-(Acetic acid)Pyridine;Phosphonic acid,P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-;P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis-phosphonic acid;Risedronic acid (Actonel)
CAS:105462-24-6
MF:C7H11NO7P2
MW:283.11
EINECS:600-654-2
Product Categories:API;(intermediate of risedronate sodium;Risedronate
Mol File:105462-24-6.mol
Risedronic acid Structure
Risedronic acid Chemical Properties
Melting point >232°C (subl.)
Boiling point 692.3±65.0 °C(Predicted)
density 1.870±0.06 g/cm3(Predicted)
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility Aqueous Base (Slightly), Methanol (Very Slightly, Heated, Sonicated)
form Solid
pka1.41±0.10(Predicted)
color White to Off-White
Stability:Hygroscopic
InChIInChI=1S/C7H11NO7P2/c9-7(16(10,11)12,17(13,14)15)4-6-2-1-3-8-5-6/h1-3,5,9H,4H2,(H2,10,11,12)(H2,13,14,15)
InChIKeyIIDJRNMFWXDHID-UHFFFAOYSA-N
SMILESC(P(=O)(O)O)(P(=O)(O)O)(O)CC1=CC=CN=C1
CAS DataBase Reference105462-24-6(CAS DataBase Reference)
EPA Substance Registry SystemPhosphonic acid, P,P'-[1-hydroxy-2-(3-pyridinyl)ethylidene]bis- (105462-24-6)
Safety Information
Hazardous Substances Data105462-24-6(Hazardous Substances Data)
MSDS Information
Risedronic acid Usage And Synthesis
UsesRisedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor. It is a potentially useful biophosphonate for bone resorption analysis.
DefinitionChEBI: Risedronic acid is a member of pyridines. It is a third generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease. It functions by preventing resorption of bone.
in vivo

Risedronic acid (Risedronate) (30 μg/kg; subcutaneous injection; once every other day; 3 weeks) prevents radiation-induced osteoporosis in female C57BL/6 mice irradiated with 2 Gy X-rays, inhibits trabecular bone loss and microstructural damage, and suppresses the increase in osteoclast number and serum TRAP5b2.
Risedronic acid (10-25 mg/kg; intraperitoneal injection; once a day; 7 days) inhibits parasitemia in BALB/c mice infected with?Plasmodium berghei?strain ANKA, but does not prolong the survival time of mice3.

Animal Model:Female C57BL/6 mice (20-week-old, ~23 g) irradiated with 2 Gy X-rays whole-body2
Dosage:30 μg/kg
Administration:Subcutaneous injection, once every other day, for 3 weeks
Result:Prevented the radiation-induced increase in osteoclast number, surface, and TRAP5b.
Animal Model:Male BALB/c mice (3-4 weeks old) infected with?Plasmodium berghei?strain ANKA by intraperitoneal injection of?1×106?blood-stage parasites3
Dosage:10 mg/kg, 15 mg/kg, 20 mg/kg, 25 mg/kg
Administration:Intraperitoneal injection, once a day, for 7 days
Result:Led to an 88.9% inhibition of the rodent parasite Plasmodium berghei in mice on the seventh day of treatment.
Mode of actionRisedronatic acid binds to bone hydroxyapatite. Bone resorption causes local acidification, releasing risedronic acid which is that taken into osteoclasts by fluid-phase endocytosis. Endocytic vesicles are acidified, releasing risedronic acid to the cytosol of osteoclasts where they induce apoptosis through inhbition of farnesyl pyrophosphate synthase. Inhibition of osteoclasts results in decreased bone resorption.
Tag:Risedronic acid(105462-24-6) Related Product Information
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