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羰基氰化氯苯腙

羰基氰化氯苯腙

中文名稱羰基氰化氯苯腙
中文同義詞羰基氰酯-3-氯苯基腙,98%;羰基氰化間氯苯腙;羰基氰基3-氯苯腙/羰基氰化氯苯腙/CCCP;氰化羰基-3-氯苯腙;氰化羰基間氯苯腙;羰基氰酯-3-氯苯基腙;羰基氰化氯苯腙;羰基氰基3-氯苯腙
英文名稱CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
英文同義詞[(3-chlorophenyl)hydrazono]-propanedinitril;m-chlorophenylcarbonylcyanidehydrazone;mesoxalonitrile,(m-chlorophenyl)hydrazone;M-CL-CCP;MESOXALONITRILE (3-CHLOROPHENYL)HYDRAZONE;BUTTPARK 91\04-41;CARBONYL CYANIDE M-CHLOROPHENYL-HYDRAZONE;CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
CAS號(hào)555-60-2
分子式C9H5ClN4
分子量204.62
EINECS號(hào)209-103-7
相關(guān)類別抑制劑;化工原料;有機(jī)化工原料;標(biāo)準(zhǔn)品;Caspases/Apoptosis
Mol文件555-60-2.mol
結(jié)構(gòu)式羰基氰化氯苯腙 結(jié)構(gòu)式

羰基氰化氯苯腙 性質(zhì)

熔點(diǎn)170-175 °C (dec.)
沸點(diǎn)333.84°C (rough estimate)
密度1.3807 (rough estimate)
折射率1.6110 (estimate)
儲(chǔ)存條件-20°C
溶解度甲醇:10 mg/mL,澄清,深的黃色
形態(tài)粉末
酸度系數(shù)(pKa)6.00±0.10(Predicted)
顏色黃色至橙色粘性至蠟狀
水溶解性Insoluble in water. Soluble in DMSO (5 mg/ml), ethanol (1 mg/ml) and methanol (10 mg/ml).
BRN1842102
暴露限值NIOSH: IDLH 25 mg/m3
InChIKeyUGTJLJZQQFGTJD-UHFFFAOYSA-N
CAS 數(shù)據(jù)庫555-60-2(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息Propanedinitrile, [(3-chlorophenyl)hydrazono]- (555-60-2)

羰基氰化氯苯腙 用途與合成方法

CCCP (Carbonyl cyanide m-chlorophenyl hydrazone, Carbonyl cyanide 3-chlorophenylhydrazone)是一種氧化磷酸化抑制劑,是線粒體質(zhì)子載體解偶聯(lián)劑,可增加線粒體膜對(duì)質(zhì)子的通透性,從而破壞線粒體膜電位。

STING
IFN-β

CCCP inhibits IFN-β production induced by various types of the STING pathway activators. CCCP suppresses the phosphorylation of STING, TBK1, and IRF3 via disrupting the association of STING and TBK1. CCCP inhibits activation of STING and its downstream signaling molecules, TBK1 and IRF3, but not STING translocation to the perinuclear region. CCCP impairs the interaction between STING and TBK1 and concomitantly triggers mitochondria fission. Importantly, the knockout of the crucial mitochondria fission regulator Drp1 restored the STING activity, indicating that CCCP down-modulates the STING pathway through DRP1-mediated mitochondria fragmentation. The protonophore CCCP that disrupts membrane potential suppresses the DMXAA-triggered STING signaling pathway. CCCP drastically suppresses the production of IFN-β in DMXAA-treated RAW264.7 cells and MEFs.

The same dosage of 3?mg/kg.bw each of CCCP and PPEF is used. In both the cases 1?log reduction is observed in the bacterial load. However, when 3?mg/kg.bw of PPEF is used in combination with 3?mg/kg.bw of CCCP, 6 log 10 reduction is observed in the bacterial count. The developed model validates the enhanced antibacterial activity of combination therapy. 99m Tc-MIBI signals in the hearts of SD rats administered CCCP (4 mg/kg intraperitoneally) or vehicle is also measured. 99m Tc-MIBI signals decrease in rat hearts administered CCCP, and the ATP content, as measured by 31 P magnetic resonance spectroscopy, decreased simultaneously. To investigate whether CCCP decreased the 99m Tc-MIBI signals in rats, we analyzed the radioisotope activity of excised heart tissue from rats administered CCCP. At 180 min after 99m Tc-MIBI injection, the 99m Tc-MIBI signals from the hearts in the CCCP group are significantly lower than those in the vehicle group.

安全信息

危險(xiǎn)品標(biāo)志T
危險(xiǎn)類別碼23/24/25-36/37/38
安全說明26-36/37-45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 3
WGK Germany3
RTECS號(hào)FG5600000
TSCAYes
危險(xiǎn)等級(jí)6.1
包裝類別III
海關(guān)編碼29280090

MSDS信息

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更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2025/05/22L06932羰基氰酯-3-氯苯基腙, 98%
Carbonyl cyanide 3-chlorophenylhydrazone, 98%
555-60-2100mg319元
2025/05/22L06932羰基氰酯-3-氯苯基腙, 98%
Carbonyl cyanide 3-chlorophenylhydrazone, 98%
555-60-2500mg713元

羰基氰化氯苯腙 上下游產(chǎn)品信息

"羰基氰化氯苯腙"相關(guān)產(chǎn)品信息
米酵菌酸銨鹽標(biāo)準(zhǔn)品 碳酰氰-4-三氟甲氧基苯腙 3-氯苯肼鹽酸鹽 甲基肼 鹽酸肼 丙二腈 間氯苯胺 鹽酸苯胺 丙腈 水合肼 羰基氰化氯苯腙 苯肼 鹽酸苯肼 丙酮苯腙
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