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| | (-)-Corey lactone 4-phenylbenzoate alcohol Basic information | | Description |
| Product Name: | (-)-Corey lactone 4-phenylbenzoate alcohol | | Synonyms: | (3AALPHA,4ALPHA,5BETA,6AALPHA)-(-)-HEXAHYDRO-4-(HYDROXYMETHYL)-2-OXO-2H-CYCLOPENTA[B]FURAN-5-YL 1,1'-BIPHENYL-4-CARBOXYLATE;4-Phenylbenzoyl corey lactone;(-)-COREY LACTONE 4-PHENYLBENZOATE ALCOHOL 99%;(3aR,4S,5R,6aS)-Hexahydro-4-hydroxymethyl-5-(4-phenylbenzoyloxy)cyclopenta[b]furan-2-one, 99%;[1,1'-Biphenyl]-4-carboxylicacid,(3aR,4S,5R,6aS)-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-ylester;BPCOD;(-) Corey lactone phenylbenzoate;(-)-Corey lactone 4-phenylbenzoate alcohol | | CAS: | 31752-99-5 | | MF: | C21H20O5 | | MW: | 352.38 | | EINECS: | 608-667-5 | | Product Categories: | Prostaglandins;Latanoprost;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 31752-99-5.mol |  |
| | (-)-Corey lactone 4-phenylbenzoate alcohol Chemical Properties |
| Melting point | 131-132 °C(lit.) | | alpha | -89 º (c=1, CHCl3) | | Boiling point | 446°C (rough estimate) | | density | 1.1818 (rough estimate) | | refractive index | 1.5400 (estimate) | | storage temp. | 2-8°C | | solubility | Chloroform, Ethyl Acetate | | form | Solid | | pka | 14.79±0.10(Predicted) | | color | Off-White to Pale Yellow | | optical activity | [α]20/D 87°, c = 1 in chloroform | | Water Solubility | insoluble | | BRN | 1294692 | | InChIKey | SZJVIFMPKWMGSX-UHFFFAOYSA-N | | CAS DataBase Reference | 31752-99-5(CAS DataBase Reference) |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 29322090 |
| | (-)-Corey lactone 4-phenylbenzoate alcohol Usage And Synthesis |
| Description | (-)-Corey lactone 4-phenylbenzoate alcohol is one of the isomers of biphenyl-4-formylcorilactone, which can be used for the synthesis of prostaglandins. Prostaglandins are a class of important endogenous physiologically active substances, important mediators of various physiological processes, and have high pharmacological activity. Clinically, prostaglandins are all artificially synthesized. | | Chemical Properties | Off-White to Pale Yellow Solid | | Uses | (-) Corey lactone phenylbenzoate is a key intermediate in the synthesis of prostaglandins. Versatile building block for prostaglandins. Building block for a potent and selective antiglaucoma agent analog of PGF2α. |
| | (-)-Corey lactone 4-phenylbenzoate alcohol Preparation Products And Raw materials |
| Preparation Products | (+)-(3AR,4R,5R,6AS)-HEXAHYDRO-5-HYDROXY-4-[(1E,3R)-3-HYDROXY-4-(3-TRIFLUOROMETHYL)PHENOXY-1-BUTENYL]-2H-CYCLOPENTA[B]FURAN-2-ONE-->(+)-Cloprostenol-->Latanoprost Lactone Diol-->[1,1'-Biphenyl]-4-carboxylic acid [3aR-[3aa,4a(E),5b,6aa]]-4-[4-(3-chlorophenoxy)-3-oxo-1-butenyl]hexahydro-2-oxo-2H-cyclopenta[b]furan-5-yl ester-->[1,1'-Biphenyl]-4-carboxylic acid (3aR,4R,5R,6aS)-hexahydro-2-oxo-4-[(1E)-3-oxo-4-[3-(trifluoromethyl)phenoxy]-1-buten-1-yl]-2H-cyclopenta[b]furan-5-yl ester |
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