黃素腺嘌呤二核苷酸
| 中文名稱 | 黃素腺嘌呤二核苷酸 |
|---|---|
| 中文同義詞 | 氟-氨碇;腺嘌呤黃素二核苷酸;二核苷酸核黃素腺苷;二核苷酸黃素腺嘌呤;核黃素腺苷雙核苷酸;黃素腺嘌呤二核苷酸;腺嘌呤黃素;腺[嘌呤]黃素二苷酸 |
| 英文名稱 | Flavin adenine dinucleotide |
| 英文同義詞 | adenine-flavindinucleotide;adenine-flavinedinucleotide;adenine-riboflavindinuceotide;flavitan;isoalloxazine-adeninedinucleotide;riboflavin5’-(trihydrogendiphosphate),5’.fwdarw.5’-esterwithadenosine;riboflavin5’-(trihydrogendiphosphate),5’-5’-esterwithadenosine;riboflavin-adeninedinucleotide |
| CAS號 | 146-14-5 |
| 分子式 | C27H33N9O15P2 |
| 分子量 | 785.55 |
| EINECS號 | 205-663-1 |
| 相關類別 | 多核苷酸類;核酸類;生物化學品;合成材料中間體;化工原料;Substrates;Biochemistry;Vitamin Derivatives;Vitamins;Aromatics;Bases & Related Reagents;Heterocycles;Isotope Labelled Compounds;Nucleotides;輔酶;Phosphorylating and Phosphitylating Agents |
| Mol文件 | 146-14-5.mol |
| 結構式 |  |
黃素腺嘌呤二核苷酸 性質
| 密度 | 2.08±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | −20°C |
| 溶解度 | 可溶于甲醇（輕微加熱）、水（輕微） |
| 酸度系數(shù)(pKa) | 1.13±0.50(Predicted) |
| 形態(tài) | 粉末 |
| 顏色 | 橙色 |
| Merck | 4091 |
| 穩(wěn)定性 | 穩(wěn)定的。與強氧化劑不相容。 |
| InChIKey | VWWQXMAJTJZDQX-ZGGJIJKNNA-N |
| CAS 數(shù)據(jù)庫 | 146-14-5 |
| EPA化學物質信息 | Riboflavin 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with adenosine (146-14-5) |
黃素腺嘌呤二核苷酸（英語：FAD），又稱活性型維生素B2、核黃素-5'-腺苷二磷酸，是一種參與了重要的代謝反應的氧化還原輔酶。FAD是一種比NAD和NADP更強的氧化劑，能被1個電子或2個電子途徑還原。其可用于標記黃嘌呤腺嘌呤氧化酶，核黃素激酶腫瘤壞死因子受體1 NADPH氧化酶。
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Human Endogenous Metabolite
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Poly(Flavin adenine dinucleotide, FAD) characterized by an additional polymer-type redox reaction is a highly effective electrocatalyst for NADH oxidation: operating at the lowest potentials reported for NADH transducers (0.00 V, pH 7.4), poly(FAD) is characterized by the electrochemical rate constant of 1.8 ± 0.6×10 -3 cm/s, which is at the level of the NADH mass-transfer constant. Poly(FAD)-modified electrodes are characterized by the dramatically improved stability and, is the most advantageous NADH transducers for analytical chemistry.
Flavin adenine dinucleotide (2 mg/kg, i.v.) significantly cancels chlorpromazine (CPZ)-induced decrease in ventricular fibrillation threshold (VFT). Flavin adenine dinucleotide cancels the effect of CPZ on canine heart mitochondria. After injection of Flavin adenine dinucleotide, the dogs show a transient hypotension within 10 min, then their blood pressures recover to the initial level. Flavin adenine dinucleotide also prevents mitochondrial dysfunction induced by chlorpromazine.