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4-羥基壬烯醛

4-羥基壬烯醛

中文名稱4-羥基壬烯醛
中文同義詞4-羥基壬烯醛;(E)-4-羥基-2-壬烯醛;4-羥基壬醛;干冰運輸]4-羥基壬烯醛;魚4-羥基壬烯酸(4-HNE)ELISA試劑盒;ANTI-4 HYDROXYNONENAL ANTIBODY-4-羥基壬烯醛抗體;反式-4-羥基-2-壬烯醛;4-羥基壬烯醛抗體
英文名稱HNE
英文同義詞Ccris 1781;(E)-4-HYDROXYNONENAL;HNE;(+/-)-4-HYDROXY-2E-NONENAL;(+/-)-4-HYDROXYNON-2-ENAL;4-hydroxy-2-nonena;2-Nonenal, 4-hydroxy-, (2E)-;Mouse 4-Hydroxy-2-nonenal elisa kit
CAS號75899-68-2
分子式C9H16O2
分子量156.22
EINECS號
相關(guān)類別生化試劑;試劑盒-Elisa試劑盒;小分子
Mol文件75899-68-2.mol
結(jié)構(gòu)式4-羥基壬烯醛 結(jié)構(gòu)式

4-羥基壬烯醛 性質(zhì)

沸點125-127 °C(Press: 2 Torr)
密度0.941±0.06 g/cm3(Predicted)
儲存條件-70°C
溶解度DMF:>50mg/mL; DMSO:>50mg/mL;乙醇:>50mg/mL; PBS pH 7.2:>1 mg/mL
酸度系數(shù)(pKa)13.31±0.20(Predicted)
形態(tài)無色油狀物。
顏色無色至淺黃
CAS 數(shù)據(jù)庫75899-68-2(CAS DataBase Reference)

4-羥基壬烯醛 用途與合成方法

4-Hydroxynonenal (4-HNE) 是一種 α,β 不飽和羥基烯醛,是一種氧化/亞硝化應(yīng)激生物標(biāo)志物。4-Hydroxynonenalal 是 ALDH2 的底物和抑制劑。4-Hydroxynonenalal 可以調(diào)節(jié)許多信號傳導(dǎo)過程,主要是通過與蛋白質(zhì),核酸和膜脂質(zhì)中具有親核官能團(tuán)的共價加合物形成的。4-Hydroxynonenalal 通過線粒體在癌癥中起重要作用。

Human Endogenous Metabolite

4-Hydroxynonenal is both a substrate and an inhibitor of ALDH2; inhibition of ALDH2 by 4-Hydroxynonenal is reversible at low concentration and become irreversible when the concentration of 4-HNE reaches 10 μM.
4-Hydroxynonenal can induce antioxidant defense mechanisms to restrain its own production and to enhance the cellular protection against oxidative stress.
4-Hydroxynonenal, the product of lipid peroxidation, is mutagenic and genotoxic in viruses, bacteria and mammalian cells. It reacts with all four DNA bases but with different efficiency: G >C > A >T. 4-Hydroxynonenal-dG represents the best biomarker of the genotoxic effects of 4-Hydroxynonenal and these adducts are primarily found in nuclear DNA. A classic example of etiological relevance of 4-Hydroxynonenal-dG in human cancers is 4-Hydroxynonenal-dG induced p53 mutation. 4-Hydroxynonenal-dG adducts were preferentially formed at the third base of codon 249 in the p53 gene, causing gene mutation and affecting diverse biological processes including cell cycle arrest, apoptosis, DNA repair, and differentiation.

Following 24 h after fluid percussion injury (FPI), the mouse brain tissue is analyzed for the expression level of NADPH oxidase 1 (NOX1), inducible nitric oxide synthase (iNOS), 4-Hydroxynonenal (4-HNE. Both wild-type (Nrf2 +/+ ) and Nrf2-deficient mice (Nrf2 ?/? ) results in increased expression of 4-Hydroxynonenal following 15 psi injury (moderate injury) when compared to uninjured Nrf2 +/+ and Nrf2 ?/? mice. Similar to iNOS result, in Nrf2 ?/? KO mice, the expression level of 4-Hydroxynonenal is significantly high when compared to corresponding injured and uninjured Nrf2 +/+ WT animals.

安全信息

MSDS信息

更新日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/08HY-1134664-Hydroxynonenal1 mg480元
2024/11/08HY-1134664-羥基壬烯醛
4-Hydroxynonenal
75899-68-25 mg1200元
"4-羥基壬烯醛"相關(guān)產(chǎn)品信息
四氯化鈦 谷胱甘肽
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