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Standard

In the analysis work, it often demanded to apply high-quality compound with the exact content being accurate in order to be compared as the detection control or used to calibrate the instrument, the compound is known as standard sample.
Standard refers to the standard substance used for measuring the potency of biological products. When the production department submits to a higher authority for approval of the quality standard of the biological product, they should also provide the standard sample (indicated in unit (μ)) used for measuring the potency of the tested product.

According to different application, the verification products can be divided into biological standard for the testing of biological products, endocrine drugs, antibiotics and other bioassay and chemical standards including:
1 chemical standards used for calibration of the instrument;
2 chemical reference standards used for calibration of the ultraviolet or infrared spectrum of the drugs;
3 control standards used for the purity test of drugs as well as the impurity control or as the control standards for content determination of the medicine.

In the page 67 of the appendix in the People's Republic of China Pharmacopoeia 1990 1st edition, we can find hundreds kinds of standards including bornyl ester acetate, eugenol and panaxadiol as well as 39 kinds of control medicine for the purify inspection of traditional Chinese medicine, impurity control or the content determination.

International standards
This refers to standard sample, with the potency units of the existing international standard sample potency units as baseline, undergoing further calibration of its potency units on the basis of a wide range of international cooperation. Its potency is expressed in 1U. For a certain product, for the establishment of the first international standard sample, the determination of its potency units should be consulted and decided by the Committee of Experts before the announcement. The international standard is a standard reference substance for worldwide preparation of national standards, so that the international standards can achieve unity.

Reagents and standards
All reagents in the food analysis laboratories should be clearly labeled to indicate the following: 1 name; 2 the date of preparation; 3 Signature from the people in charge; 4 if necessary, we need to add content such as safety and validity and so on.
Most food analysis should use standard sample as reference for qualitative and quantitative determination. The standard sample should be classified according to the following classification methods: 1 international standard; 2 national standards; 3 internal standard; 4 other standards.
Receptacle for reference standards should be clearly affixed to the label, to indicate the following: 1 name; 2 standard document number; 3 Opening times; 4 Validity; 5 Signature.
In addition, the laboratory should keep all the necessary specific files for all the necessary reference standards.
Capacity analysis standard solution should also be strictly managed. It should be clearly posted on all the standard solution containers with labels to indicate: 1 name; 2 concentration; 3 formulation date; 4 No of formulated procedures; 5 storage conditions; 6 validity; 7 Signature from people in charge.

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Structure Chemical Name CAS MF
Dapagliflozin Impurity 19 Dapagliflozin Impurity 19 1469910-84-6 C29H33ClO10
Docetaxel EP Impurity A Docetaxel EP Impurity A
Empagliflozin Impurity 21 Empagliflozin Impurity 21
Febuxostat Impurity 43 Febuxostat Impurity 43
Formoterol Impurity 20 Formoterol Impurity 20
Hydroxychloroquine Impurity 2 Hydroxychloroquine Impurity 2
Ibrutinib Impurity 14 Ibrutinib Impurity 14 2417548-76-4 C50H48N12O4
Imatinib impurity 11 Imatinib impurity 11
Isavuconazole Impurity 2 Isavuconazole Impurity 2 2001051-99-4 C13H12F2N4O
Isavuconazole Impurity 25 Isavuconazole Impurity 25
Loxoprofen Impurity 18 Loxoprofen Impurity 18 99807-54-2 C11H13BrO2
Mupirocin EP Impurity D Mupirocin EP Impurity D 71087-97-3 C26H44O9
N-Acetyl-Lys-Octreotide N-Acetyl-Lys-Octreotide 173606-11-6 C51H68N10O11S2
Olaparib Impurity 3 Olaparib Impurity 3
Posaconazole Impurity 33 Posaconazole Impurity 33 182210-71-5 C12H13F2IO2
Posaconazole Impurity 38 Posaconazole Impurity 38
Posaconazole Impurity 62 Posaconazole Impurity 62
Roxithromycin Impurity J Roxithromycin Impurity J
Sitagliptin Impurity 21 Sitagliptin Impurity 21 2088771-60-0 C20H19F6N5O5
SofosBuvir Impurity 38 SofosBuvir Impurity 38
SofosBuvir Impurity 61 SofosBuvir Impurity 61
Suvorexant Impurity 2 Suvorexant Impurity 2 1276666-19-3 C23H23ClN6O2
Tenofovir impurity L Tenofovir impurity L
Ticagrelor Impurity 27 Ticagrelor Impurity 27 1402150-01-9 C19H26ClN5O5S
Ticagrelor impurity P Ticagrelor impurity P
Tramadol Impurity 1 Tramadol Impurity 1 66170-32-9 C16H25NO2
Lidocaine EP Impurity G Lidocaine EP Impurity G 42459-30-3 C13H20N2O
methyl 1,4-dihydroxy-7-phenoxyisoquinoline-3-carboxylate methyl 1,4-dihydroxy-7-phenoxyisoquinoline-3-carboxylate 1421312-32-4 C17H13NO5
1-(2,3-DIMETHYLPHENYL)PROPAN-1-OL 1-(2,3-DIMETHYLPHENYL)PROPAN-1-OL 944268-64-8 C11H16O
4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 4-(4-chlorophenyl)-5-methyl-3-phenylisoxazole 1448355-87-0 C16H12ClNO
Enrofloxacin EP Impurity C Enrofloxacin EP Impurity C 138892-82-7 C19H23N3O3
Pregabalin Lactam (S)-Isomer Lactose Adduct Pregabalin Lactam (S)-Isomer Lactose Adduct 466678-44-4 C20H35NO11
Ertapenem Impurity Pro-maba Ertapenem Impurity Pro-maba 724700-26-9 C12H14N2O3
Empagliflozin Impurity 22 Empagliflozin Impurity 22
Empagliflozin Impurity 35 Empagliflozin Impurity 35 1459754-40-5 C13H8ClIO2
tirofiban tirofiban 464175-13-1 C9H18ClN
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-4,8,11-trifluoroacetyl- 1-yl)methyl)benzyl)-4,11-difluoroacetyl-1,4,8,11- tetraazacyclotetradecane 1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-4,8,11-trifluoroacetyl- 1-yl)methyl)benzyl)-4,11-difluoroacetyl-1,4,8,11- tetraazacyclotetradecane
Fulvestrant Impurity 4 Fulvestrant Impurity 4 1621885-82-2 C30H44O6S
Clopidogrel Clopidogrel 1360923-54-1 C16H16ClNO3S
Ozagrel-015 Ozagrel-015 1332370-00-9 C10H10O3
Piperacillin Sulfoxide Piperacillin Sulfoxide 67275-27-8 C23H27N5O8S
Budesonide Impurity 11 Budesonide Impurity 11 39672-76-9 C21H26O5
1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl) benzyl)-1,4,8,11-tetraazacyclotetradecane dodecahydrochloride 1,8-bis(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl) benzyl)-1,4,8,11-tetraazacyclotetradecane dodecahydrochloride 2173049-85-7 C46H85ClN12
Mirabegron Impurity 26 Mirabegron Impurity 26 91828-74-9 C8H9N3O4
Alosetron Impurity 1 Alosetron Impurity 1 1011293-30-3 C17H16N4O2
2-(3-cyano-4-isobutoxyphenyl)-N,N,4-trimethylthiazole-5- carboxamide 2-(3-cyano-4-isobutoxyphenyl)-N,N,4-trimethylthiazole-5- carboxamide 1380049-45-5 C18H21N3O2S
Acarbose Impurity F Acarbose Impurity F
Oseltamivir  Impurity 10 Oseltamivir Impurity 10 2081110-43-0 C16H28N2O4
Pitavastatin Impurity 41 Pitavastatin Impurity 41
Rivaroxaban Impurity 14 Rivaroxaban Impurity 14 1429334-02-0 C15H21N3O4
Ticagrelor Impurity 69 Ticagrelor Impurity 69
Tofacitinib Impurity 71 Tofacitinib Impurity 71
Tofacitinib Impurity 79 Tofacitinib Impurity 79
Topiroxostat Impurity 5 Topiroxostat Impurity 5 2050015-91-1 C7H6N4O
Canagliflozin-10 Canagliflozin-10 2161394-94-9 C24H25FO5S
2-amino-N-(2-methylphenyl)-5-thiazolecarboxamide 2-amino-N-(2-methylphenyl)-5-thiazolecarboxamide 1184914-03-1 C11H11N3OS
Afatinib Impurity 23 Afatinib Impurity 23 1314777-66-6 C8H4FN3O3
Atracurium Impurity 25 Atracurium Impurity 25 86682-55-5 C20H25NO5
Aztreonam Impurity 7 Aztreonam Impurity 7
Canagliflozin Impurity 43 Canagliflozin Impurity 43
Carvedilol Impurity 2 Carvedilol Impurity 2 1198090-71-9 C18H17NO3
Clotrimazole Impurity 2 Clotrimazole Impurity 2
Dapagliflozin Impurity 33 Dapagliflozin Impurity 33
Erlotinib Impurity 56 Erlotinib Impurity 56
Moxifloxacin Impurity 8 Moxifloxacin Impurity 8 1829588-19-3 C21H25N3O5
Olaparib Impurity 30 Olaparib Impurity 30 1460272-52-9 C24H21FN4O4
Pitavastatin Impurity 27 Pitavastatin Impurity 27
Pramipexole Impurity 24 Pramipexole Impurity 24
Rocuronium Bromide Impurity 22 Rocuronium Bromide Impurity 22
Tolterodine Impurity 1 Tolterodine Impurity 1 88407-28-7 C22H31NO
Voriconazole Impurity 7 Voriconazole Impurity 7 239807-04-6 C16H14F3N5O
Apremilast Impurity SJM Apremilast Impurity SJM
Aprepitant Impurity 28 Aprepitant Impurity 28
AZD9291 Osimertinib Impurity 3 AZD9291 Osimertinib Impurity 3
Dextrorotation lansoprazole Impurity K Dextrorotation lansoprazole Impurity K
Doxofylline Impurity A Doxofylline Impurity A
lansoprazole Impurity 24 lansoprazole Impurity 24
lansoprazole Impurity 30 lansoprazole Impurity 30
meta-dyhydroxy Sugammadex sodium Impurity 2 meta-dyhydroxy Sugammadex sodium Impurity 2
Palbociclib Impurity 29 Palbociclib Impurity 29
Palbociclib Impurity 34 Palbociclib Impurity 34
Ropivacaine Impurity 38 Ropivacaine Impurity 38
Ropivacaine Impurity 43 Ropivacaine Impurity 43 2726971-51-1
Sugammadex sodium Decomposition process Impurity 1 Sugammadex sodium Decomposition process Impurity 1
Sugammadex sodium Org198786-1 Impurity Sugammadex sodium Org198786-1 Impurity
Sugammadex sodium starting material Impurity 1 Sugammadex sodium starting material Impurity 1
Fludarabine EP impurity H Fludarabine EP impurity H 548774-57-8 C10H10FN5O3
Afatinib impurity 31 Afatinib impurity 31
Butyphthalide impurity 30 Butyphthalide impurity 30
Cabozantinib impurity S Cabozantinib impurity S
Canagliflozin Isomer Impurity 1 Canagliflozin Isomer Impurity 1
Celecoxib Impurity 19 Celecoxib Impurity 19 C17H14F3N3O2S
Febuxostat Impurity 81 Febuxostat Impurity 81
Gefitinib Impurity Q Gefitinib Impurity Q
Irinotecan Impurity 20 HCl Irinotecan Impurity 20 HCl 870527-52-9 C20H20N2O4
LCZ696(valsartan + sacubitril) impurity 32 LCZ696(valsartan + sacubitril) impurity 32
Lenvatinib Impurity 25 Lenvatinib Impurity 25
Leosimendan azide Impurity Leosimendan azide Impurity
Regorafenib Impurity 23 Regorafenib Impurity 23
Regorafenib Impurity 31 Regorafenib Impurity 31
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