セニカポク
|
- ￥132900 - ￥398800
- 化學(xué)名: セニカポク
- 英語(yǔ)名: Senicapoc
- 別名:セニカポク
- CAS番號(hào): 289656-45-7
- 分子式: C20H15F2NO
- 分子量: 323.34
- EINECS:
- MDL Number:MFCD09027349
2物価
選択條件：
ブランド
- 富士フイルム和光純薬株式會(huì)社(wako)
パッケージ
- 250mg
- 1g
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01MAS094238
- 製品説明
- 英語(yǔ)製品説明2,2-Bis(4-fluorophenyl)-2-phenylacetamide
- 包裝単位1g
- 価格￥398800
- 更新しました2024-03-01
- 購(gòu)入
- 生産者富士フイルム和光純薬株式會(huì)社(wako)
- 製品番號(hào)W01MAS094238
- 製品説明
- 英語(yǔ)製品説明2,2-Bis(4-fluorophenyl)-2-phenylacetamide
- 包裝単位250mg
- 価格￥132900
- 更新しました2024-03-01
- 購(gòu)入
| 生産者 | 製品番號(hào) | 製品説明 | 包裝単位 | 価格 | 更新時(shí)間 | 購(gòu)入 |
|---|---|---|---|---|---|---|
| 富士フイルム和光純薬株式會(huì)社(wako) | W01MAS094238 | 2,2-Bis(4-fluorophenyl)-2-phenylacetamide |
1g | ￥398800 | 2024-03-01 | 購(gòu)入 |
| 富士フイルム和光純薬株式會(huì)社(wako) | W01MAS094238 | 2,2-Bis(4-fluorophenyl)-2-phenylacetamide |
250mg | ￥132900 | 2024-03-01 | 購(gòu)入 |
プロパティ
融點(diǎn) :180-181 °C(Solv: hexane (110-54-3); dichloromethane (75-09-2))
沸點(diǎn) :460.7±45.0 °C(Predicted)
比重(密度) :1.250±0.06 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
外見(jiàn) :Powder
酸解離定數(shù)(Pka) :15.41±0.50(Predicted)
色 :White to yellow
InChI :InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey :SCTZUZTYRMOMKT-UHFFFAOYSA-N
SMILES :C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N
沸點(diǎn) :460.7±45.0 °C(Predicted)
比重(密度) :1.250±0.06 g/cm3(Predicted)
貯蔵溫度 :Sealed in dry,Store in freezer, under -20°C
溶解性 :DMSO : 50 mg/mL (154.64 mM; Need ultrasonic)
外見(jiàn) :Powder
酸解離定數(shù)(Pka) :15.41±0.50(Predicted)
色 :White to yellow
InChI :InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24)
InChIKey :SCTZUZTYRMOMKT-UHFFFAOYSA-N
SMILES :C(C1C=CC=CC=1)(C1C=CC(F)=CC=1)(C1C=CC(F)=CC=1)C(=O)N
安全情報(bào)
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説明
Senicapoc is an inhibitor of intermediate conductance calcium-activated potassium (IKCa1/KCa3.1) channels. It inhibits rubidium efflux from and dehydration of isolated human red blood cells (RBCs) induced by the calcium ionophore A23187 (; IC50s = 11 and 30 nM, respectively). Senicapoc (10 mg/kg twice per day) reduces IKCa1/KCa3.1 channel activity, increases potassium levels in RBCs, and decreases erythrocyte density in the SAD transgenic mouse model of sickle cell disease. It inhibits IL-2, IFN-γ, IL-12, and IL-17A production in CD3+ T cells stimulated with phorbol 12-myristate 13-acetate (PMA; ) and ionomycin (Item Nos. 10004974 | 11932) when used at a concentration of 1 μM. Senicapoc (100 mg/kg) increases the paw withdrawal threshold in a rat model of chronic constriction injury (CCI) of the sciatic nerve.関連商品価格
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