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ChemicalBook >> CAS DataBase List >> KO-947

KO-947

KO-947 price.
  • $32 - $1650
  • Product name: KO-947
  • CAS: 1695533-89-1
  • MF: C21H17N5O
  • MW: 355.39
  • EINECS:
  • MDL Number:MFCD31657422
  • Synonyms:KO-947;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;KO947;KO-947;KO 947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;6-benzyl-3-(pyridin-4-yl)-1H,5H,6H,7H,8H-pyrazolo[4,3-g]quinazolin-7-one
13 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
Package
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number8399EM
  • Product description6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
  • Packaging5mg
  • Price$252
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product number8399EM
  • Product description6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one
  • Packaging10mg
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number29213
  • Product descriptionKO947
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29213
  • Product descriptionKO947
  • Packaging5mg
  • Price$139
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29213
  • Product descriptionKO947
  • Packaging10mg
  • Price$243
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number29213
  • Product descriptionKO947
  • Packaging25mg
  • Price$533
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0043627
  • Product descriptionKO-947 99.45%
  • Packaging5mg
  • Price$160
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0043627
  • Product descriptionKO-947 99.45%
  • Packaging10mg
  • Price$260
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0043627
  • Product descriptionKO-947 99.45%
  • Packaging25mg
  • Price$490
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0043627
  • Product descriptionKO-947 99.45%
  • Packaging50mg
  • Price$900
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0043627
  • Product descriptionKO-947 99.45%
  • Packaging100mg
  • Price$1650
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10487
  • Product descriptionKO947 >98%
  • Packaging100mg
  • Price$750
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC10487
  • Product descriptionKO947 >98%
  • Packaging250mg
  • Price$1400
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 8399EM 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one 5mg $252 2021-12-16 Buy
AK Scientific 8399EM 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one 10mg $370 2021-12-16 Buy
Cayman Chemical 29213 KO947 1mg $32 2024-03-01 Buy
Cayman Chemical 29213 KO947 5mg $139 2024-03-01 Buy
Cayman Chemical 29213 KO947 10mg $243 2024-03-01 Buy
Cayman Chemical 29213 KO947 25mg $533 2024-03-01 Buy
ChemScene CS-0043627 KO-947 99.45% 5mg $160 2021-12-16 Buy
ChemScene CS-0043627 KO-947 99.45% 10mg $260 2021-12-16 Buy
ChemScene CS-0043627 KO-947 99.45% 25mg $490 2021-12-16 Buy
ChemScene CS-0043627 KO-947 99.45% 50mg $900 2021-12-16 Buy
ChemScene CS-0043627 KO-947 99.45% 100mg $1650 2021-12-16 Buy
DC Chemicals DC10487 KO947 >98% 100mg $750 2021-12-16 Buy
DC Chemicals DC10487 KO947 >98% 250mg $1400 2021-12-16 Buy

Properties

Boiling point :704.1±60.0 °C(Predicted)
Density :1.354±0.06 g/cm3(Predicted)
storage temp. :4°C, protect from light
solubility :DMSO:66.75(Max Conc. mg/mL);187.82(Max Conc. mM)
form :A crystalline solid
pka :13.32±0.20(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).