ChemicalBook >> CAS DataBase List >>KO-947
KO-947
- CAS No.
- 1695533-89-1
- Chemical Name:
- KO-947
- Synonyms
- KO-947;KO947;KO-947;KO 947;6-benzyl-3-(pyridin-4-yl)-1H,5H,6H,7H,8H-pyrazolo[4,3-g]quinazolin-7-one;6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one;Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947;7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-
- CBNumber:
- CB63168747
- Molecular Formula:
- C21H17N5O
- Molecular Weight:
- 355.39
- MDL Number:
- MFCD31657422
- MOL File:
- 1695533-89-1.mol
Last updated:2024-11-19 23:02:33
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
KO-947 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29213 | KO947 | 1695533-89-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29213 | KO947 | 1695533-89-1 | 25mg | $533 | 2024-03-01 | Buy |
| Cayman Chemical | 29213 | KO947 | 1695533-89-1 | 5mg | $139 | 2024-03-01 | Buy |
| Cayman Chemical | 29213 | KO947 | 1695533-89-1 | 10mg | $243 | 2024-03-01 | Buy |
| AK Scientific | 8399EM | 6-Benzyl-3-pyridin-4-yl-5,8-dihydro-1H-pyrazolo[4,3-g]quinazolin-7-one | 1695533-89-1 | 5mg | $252 | 2021-12-16 | Buy |
KO-947 Chemical Properties,Uses,Production
Description
KO947 is an ERK inhibitor (IC50 = <50 nM for ERK2). It is greater than 50-fold selective for ERK over a panel of 450 kinases. KO947 reduces phosphorylation of the ERK target p90 ribosomal S6 kinase (RSK) in A375 cancer cells containing constitutively active B-RAFV600E with an IC50 value of less than 250 nM. It inhibits proliferation of A375 cells, as well as mutant K-Ras-expressing HCT116 and H358 cancer cell lines (IC50s = 50-250 nM for all).
KO-947 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 66)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30236 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Nanjing Bicbiotechnology Co., Ltd | +86-2552131256 +86-18251840740 | sales@bicbiotech.com | China | 5994 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
KO-947
6-benzyl-3-(pyridin-4-yl)-5,6-dihydro-1H-pyrazolo[4,3-g]quinazolin-7(8H)-one
KO947;KO-947;KO 947
7H-Pyrazolo[4,3-g]quinazolin-7-one, 1,5,6,8-tetrahydro-6-(phenylmethyl)-3-(4-pyridinyl)-
Inhibitor,ERK,KO-947,inhibit,KO 947,Extracellular signal regulated kinases,KO947
6-benzyl-3-(pyridin-4-yl)-1H,5H,6H,7H,8H-pyrazolo[4,3-g]quinazolin-7-one
1695533-89-1