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20-CARBOXY-LEUKOTRIENE B4

20-CARBOXY-LEUKOTRIENE B4 ??? ???
?? ??:
80434-82-8
???:
20-CARBOXY-LEUKOTRIENE B4
???(??):
20-COOH-LTB4;20-CARBOXY-LEUKOTRIENE B4;20-hydroxy-20-oxoleukotriene B4;20-carboxy Leukotriene B4 (20-carboxy LTB4);5S,12R-DIHYDROXY-6Z,8E,10E,14Z-EICOSATETRAENE-1,20-DIOIC ACID;(5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenedioic acid;6,8,10,14-Eicosatetraenedioic acid, 5,12-dihydroxy-, (5S,6Z,8E,10E,12R,14Z)-
CBNumber:
CB9769067
???:
C20H30O6
??? ??:
366.45
MOL ??:
80434-82-8.mol

20-CARBOXY-LEUKOTRIENE B4 ??

?? ?
588.3±50.0 °C(Predicted)
??
1.151±0.06 g/cm3(Predicted)
???
14℃
?? ??
−20°C
???
DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml
??? ??
Liquid
?? ?? (pKa)
4.66±0.10(Predicted)
??
Colorless to light yellow
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? F,Xi
?? ???? ?? 11-36/37/38
????? 16-26-36
????(UN No.) UN 1170 3/PG 2
WGK ?? 3
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H225 ???? ?? ? ?? ??? ?? ?? 2 ?? GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P210 ?·???·??·????? ????? - ?? ???.
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
3
0 0

20-CARBOXY-LEUKOTRIENE B4 C??? ??, ??, ??

??

20-carboxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. The resulting 20-hydroxy LTB4 is further oxidized to 20-carboxy LTB4. LTB4 metabolism in isolated rat hepatocytes also results in production of 20-carboxy LTB4 along with other ω-oxidation products. The biological activity of 20-carboxy LTB4 is only about 2.6% compared to that of LTB4 in causing PMNL degranulation.

??

20-COOH-LTB4 is a leukotriene B4 metabolite and substrate for β-oxidation pathways.

??

ChEBI: A member of the class of leukotrienes that is leukotriene B4 in which the terminal methyl group has undergone formal oxidation to the corresponding carboxylic acid.

20-CARBOXY-LEUKOTRIENE B4 ?? ?? ? ???

???

?? ??

20-CARBOXY-LEUKOTRIENE B4 ?? ??

???( 32)?? ??
??? ?? ??? ?? ?? ? ??
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20-CARBOXY-LEUKOTRIENE B4 ?? ??:

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